UBE2B and CDKN1B

Number of citations of the paper that reports this interaction (PMID 19123975)
2

Data Source:
BioGRID (enzymatic study)

		UBE2B	CDKN1B
Gene Name		ubiquitin-conjugating enzyme E2B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)
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Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin XY Body Nucleus Replication Fork Cytoplasm Plasma Membrane HULC Complex	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Phosphatase Binding Hsp70 Protein Binding Protein Complex Binding Chaperone Binding
	Biological Process	Protein Polyubiquitination Response To Hypoxia In Utero Embryonic Development DNA Repair Postreplication Repair Maintenance Of Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Cellular Response To Insulin Stimulus Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Protein Stabilization Chiasma Assembly Protein Autoubiquitination Canonical Wnt Signaling Pathway Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Response To Hypoxia Potassium Ion Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Positive Regulation Of Cell Death Negative Regulation Of Cell Growth Positive Regulation Of Microtubule Polymerization Response To Estradiol Negative Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Phosphorylation Response To Drug Negative Regulation Of Apoptotic Process Response To Amino Acid Response To Peptide Hormone Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Response To Cadmium Ion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Autophagic Cell Death Inner Ear Development Negative Regulation Of Cellular Component Movement Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound Mitotic Cell Cycle Arrest
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Cellular Senescence p53-Dependent G1/S DNA damage checkpoint Cyclin E associated events during G1/S transition AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade G1/S Transition Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Signaling by PDGF DAP12 interactions DNA Damage/Telomere Stress Induced Senescence GAB1 signalosome Senescence-Associated Secretory Phenotype (SASP) S Phase Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR SCF(Skp2)-mediated degradation of p27/p21 Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 PI3K/AKT Signaling in Cancer Adaptive Immune System PIP3 activates AKT signaling Orc1 removal from chromatin p53-Dependent G1 DNA Damage Response PI3K events in ERBB2 signaling Downstream signaling of activated FGFR G1/S DNA Damage Checkpoints Innate Immune System Signalling by NGF Synthesis of DNA G1 Phase Regulation of DNA replication Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Cell Cycle, Mitotic Signaling by FGFR Orc1 removal from chromatin Cyclin D associated events in G1 Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Systemic lupus erythematosus ( 23273568)
Protein-Protein Interactions		19 interactors: BIRC2 CDKN1B CNOT4 CRMP1 CTNNB1 HIST2H2AC MED31 PCNA RAD18 RNF20 RNF40 TRIM45 UBA1 UBC UBR1 UBR2 UBR3 UBR5 UNC119	62 interactors: ABL1 AKT1 ARHGDIA CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE2 CDC34 CDK2 CDK3 CDK4 CDK5 CKS1B COPS5 CUL1 CUL4A GRB2 HIST1H1A HIST1H1B IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 NUP50 PIN1 PSMB1 RCHY1 RNF123 RPS6KA1 SGK1 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE3A UCHL1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		7320	1027
HPRD ID		01533	02867
Ensembl ID		ENSG00000119048	ENSG00000111276
Uniprot IDs		P63146	P46527 Q6I9V6
PDB IDs		1JAS 1NXA 2Y4W 2YB6 2YBF	1H27 1JSU 2AST
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Response To Leucine Proteolysis Histone Ubiquitination Cellular Protein Modification Process Regulation Of Protein K63-linked Ubiquitination Protein Polyubiquitination Response To Cadmium Ion Response To Leucine Histone H2B Ubiquitination Cellular Response To DNA Damage Stimulus Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Response To Amino Acid Cell Cycle Process Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process Histone Monoubiquitination Regulation Of Histone Modification Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of TOR Signaling Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organonitrogen Compound Positive Regulation Of Histone Methylation Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Chromosome Organization Negative Regulation Of Protein Metabolic Process Protein Monoubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Canonical Wnt Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cellular Metabolic Process	Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Response To Organic Substance Cell Communication Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Transferase Activity Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Process Cellular Protein Modification Process Regulation Of Metabolic Process Signal Transduction Positive Regulation Of Cell Cycle Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stimulus Protein Catabolic Process Apoptotic Process Regulation Of Intracellular Transport Programmed Cell Death Viral Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Localization Cell Death Death Positive Regulation Of Intracellular Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Organelle Organization
Tagcloud ?			aggregated anaplastic atc braf cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e
Tagcloud (Difference) ?			aggregated anaplastic atc braf cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e
Tagcloud (Intersection) ?