UBA7 and UBE2L3

Number of citations of the paper that reports this interaction (PMID 19250909)
47

Data Source:
BioGRID (enzymatic study)

		UBA7	UBE2L3
Gene Name		ubiquitin-like modifier activating enzyme 7	ubiquitin-conjugating enzyme E2L 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Ubiquitin Ligase Complex Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin Activating Enzyme Activity Ubiquitin-protein Transferase Activity ATP Binding ISG15 Activating Enzyme Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Cellular Protein Modification Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Innate Immune Response	Protein Polyubiquitination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Antiviral mechanism by IFN-stimulated genes Adaptive Immune System Innate Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Ulcerative colitis ( 21297633)	Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) HDL cholesterol ( 20686565) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517) Systemic lupus erythematosus ( 23273568 21408207 19838193)
Protein-Protein Interactions		4 interactors: FAS ISG15 UBE2L3 UBE2L6	64 interactors: ARIH1 ARIH2 ATXN3 BRCA1 CBL CBLC CCNB1IP1 CUL9 DTX3 FBXO2 FOS HACE1 HERC3 HSPA4 HUWE1 ITCH LIG4 MAPK6 MDM2 MID1 MKRN3 MUL1 NEDD4 NEDD4L NFKBIA NR3C1 PARK2 PJA1 POLR2A PTEN RAD23A RBCK1 RBX1 RELA RNF103 RNF113B RNF125 RNF144A RNF144B RNF19A RNF2 RNF216 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TRAF6 TRAF7 TRIM21 TRIM28 TRIM39 TRIP12 UBA1 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR5 WWP1 WWP2
Entrez ID		7318	7332
HPRD ID		01873	04762
Ensembl ID		ENSG00000182179	ENSG00000185651
Uniprot IDs		P41226	P68036
PDB IDs			1C4Z 1FBV 3SQV 3SY2
Enriched GO Terms of Interacting Partners?		ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Modification-dependent Protein Catabolic Process Cellular Response To Organic Substance Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Cytokine Stimulus Protein Catabolic Process Response To Cytokine Regulation Of Type I Interferon Production Response To Organic Substance Cellular Macromolecule Catabolic Process Response To Glucocorticoid Response To Corticosteroid Motor Neuron Apoptotic Process Regulation Of Myeloid Cell Differentiation Regulation Of Protein Ubiquitination Negative Regulation Of Cytokine Production Immune Response Necroptotic Signaling Pathway Proteolysis Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Cell Apoptotic Process Cellular Response To Hyperoxia Positive Regulation Of Protein Homooligomerization Catabolic Process Pantothenate Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Steroid Hormone Negative Thymic T Cell Selection Negative T Cell Selection Long-chain Fatty-acyl-CoA Biosynthetic Process Immune System Process Cellular Response To Lithium Ion T Cell Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Protein Metabolic Process Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Protein Oligomerization Hepatocyte Apoptotic Process Protein Ubiquitination Positive Regulation Of Erythrocyte Differentiation Protein K11-linked Ubiquitination Thymic T Cell Selection Acetyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Metabolic Process Protein Modification By Small Protein Conjugation	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Polyubiquitination Proteolysis Protein Metabolic Process Catabolic Process Cellular Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Viral Process Regulation Of Protein Catabolic Process Cellular Response To Organic Substance Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Protein K48-linked Ubiquitination Negative Regulation Of Signaling Protein Monoubiquitination Cellular Response To Stress Metabolic Process Protein Autoubiquitination Response To Stress Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cellular Response To Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Organic Substance Response To Growth Factor Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cytokine Production Response To Transforming Growth Factor Beta Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair Positive Regulation Of Protein Catabolic Process
Tagcloud ?			2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants
Tagcloud (Difference) ?			2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants
Tagcloud (Intersection) ?