TRPC6 and ORAI1

Number of citations of the paper that reports this interaction (PMID 17360584)
85

Data Source:
HPRD (in vivo, in vitro)

		TRPC6	ORAI1
Gene Name		transient receptor potential cation channel, subfamily C, member 6	ORAI calcium release-activated calcium modulator 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Slit Diaphragm	Integral Component Of Plasma Membrane Membrane Protein Complex
	Molecular Function	Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding	Protein Binding Calmodulin Binding Store-operated Calcium Channel Activity Identical Protein Binding
	Biological Process	Cation Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Aging Blood Coagulation Platelet Activation Positive Regulation Of Ion Transmembrane Transporter Activity Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia	Store-operated Calcium Entry Immune System Process Blood Coagulation Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport
Pathways		G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling	Signaling by the B Cell Receptor (BCR) Platelet homeostasis Elevation of cytosolic Ca2+ levels Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Platelet calcium homeostasis Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2	2 interactors: TRPC3 TRPC6
Entrez ID		7225	84876
HPRD ID		04710	08599
Ensembl ID		ENSG00000137672
Uniprot IDs		Q9Y210	Q96D31
PDB IDs			4EHQ
Enriched GO Terms of Interacting Partners?		Calcium Ion Transport Blood Coagulation Hemostasis Platelet Activation Calcium Ion Transmembrane Transport Regulation Of Body Fluid Levels Wound Healing Response To Wounding Metal Ion Transport Response To Stress Cation Transport Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ion Transport Manganese Ion Transmembrane Transport Cation Transmembrane Transport Axon Guidance Manganese Ion Transport Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Axonogenesis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ion Transmembrane Transport Response To Hydroperoxide Chemotaxis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cell Morphogenesis Involved In Differentiation Phagocytosis Peptidyl-tyrosine Autophosphorylation Fc Receptor Signaling Pathway Innate Immune Response Neuron Projection Development Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Morphogenesis Transmembrane Transport Cell Part Morphogenesis Transport Response To External Stimulus Neuron Development	Positive Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Calcium Ion Transmembrane Transport Calcium Ion Transport Axon Guidance Blood Coagulation Hemostasis Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Response To Inorganic Substance Axonogenesis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Regulation Of Ion Transport Neuron Projection Morphogenesis Cell Activation Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Neuron Projection Development Metal Ion Transport Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Cardiac Muscle Hypertrophy Cation Transmembrane Transport Neuron Development Cell Morphogenesis Response To Abiotic Stimulus Response To ATP Neuron Differentiation Cell Projection Organization Regulation Of Cardiac Muscle Hypertrophy Cation Transport Locomotion Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Movement Of Cell Or Subcellular Component Positive Regulation Of Ion Transmembrane Transporter Activity Generation Of Neurons Positive Regulation Of Transporter Activity Cellular Response To Hydrogen Peroxide Neurogenesis Transmembrane Transport Ion Transport Cell Development
Tagcloud ?		blocker ca casr channels depending elicited eliminated exchanger expressions ip3 lymphocytes nicl2 nps plc rise sensing sepsis septic skf96365 sr stores tg thapsigargin transient trpc3 u73122 verapamil	acinar agonist agonists carboxyl clustering coexpression depleted diminished dispersed glands hek intensities junctions mildly muscarinic nfat operated pm polybasic puncta recruits salivary soce stim1 stim1deltak stim2 stimulus store stores
Tagcloud (Difference) ?		blocker ca casr channels depending elicited eliminated exchanger expressions ip3 lymphocytes nicl2 nps plc rise sensing sepsis septic skf96365 sr tg thapsigargin transient trpc3 u73122 verapamil	acinar agonist agonists carboxyl clustering coexpression depleted diminished dispersed glands hek intensities junctions mildly muscarinic nfat operated pm polybasic puncta recruits salivary soce stim1 stim1deltak stim2 stimulus store
Tagcloud (Intersection) ?		stores