TRAF3 and TNFRSF8

Number of citations of the paper that reports this interaction (PMID 9168896)
14

Data Source:
HPRD (in vivo)

		TRAF3	TNFRSF8
Gene Name		TNF receptor-associated factor 3	tumor necrosis factor receptor superfamily, member 8
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding	Transmembrane Signaling Receptor Activity
	Biological Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Defense Response To Virus	Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of TRAIL Biosynthetic Process Cellular Response To Mechanical Stimulus
Pathways		Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125)
Protein-Protein Interactions		55 interactors: ABCC1 ALPL APOBEC3C AZI2 BIRC3 CASP3 CD27 CD40 DAXX EDA2R EDAR EWSR1 FAS GRIN1 GRIN2D IL15 IRF1 LTBR MAP2K1 MAP3K14 NGFRAP1 NUP62 OTUD5 PDLIM7 RIPK1 RRAS2 SAR1A SRC TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZMYND11	7 interactors: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		7187	943
HPRD ID		03539	01074
Ensembl ID		ENSG00000131323	ENSG00000120949
Uniprot IDs		A6NHG8 Q13114	A5D8T4 B9EGD9 D3YTD8 P28908
PDB IDs		1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW	1D01
Enriched GO Terms of Interacting Partners?		Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Tumor Necrosis Factor Regulation Of Cytokine Production Signal Transduction Positive Regulation Of Protein Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Extrinsic Apoptotic Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Response To Stimulus Immune Response Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Regulation Of Apoptotic Process Response To Cytokine Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Lymphocyte Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Death	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Signaling NIK/NF-kappaB Signaling Cell Communication Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Cellular Response To Tumor Necrosis Factor Toll-like Receptor Signaling Pathway Regulation Of Gene Expression Protein Ubiquitination Response To Tumor Necrosis Factor Protein Modification By Small Protein Conjugation Response To Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MAP Kinase Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Innate Immune Response Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Homodimerization Activity Regulation Of MAP Kinase Activity Toll Signaling Pathway Cellular Response To Nitric Oxide CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Immunoglobulin Secretion Response To Nitric Oxide
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction	abrogates alanine artificially ascorbate canonical cd30 cd30v checkpoint concurrently endogenously h2o2 hesc hescs makes nfkappab overexpress purification resides residue restores subcellular substitution surprisingly t61 t61a thr61 threonine traf2 unexpected
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf5 traf6 transduction	abrogates alanine artificially ascorbate canonical cd30 cd30v checkpoint concurrently endogenously h2o2 hesc hescs makes nfkappab overexpress purification resides residue restores subcellular substitution surprisingly t61 t61a thr61 threonine unexpected
Tagcloud (Intersection) ?		traf2