TRAF3 and TRAF3IP3

Number of citations of the paper that reports this interaction (PMID 14572659)
5

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		TRAF3	TRAF3IP3
Gene Name		TNF receptor-associated factor 3	TRAF3 interacting protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding	Protein Binding
	Biological Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Defense Response To Virus
Pathways		Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125)
Protein-Protein Interactions		55 interactors: ABCC1 ALPL APOBEC3C AZI2 BIRC3 CASP3 CD27 CD40 DAXX EDA2R EDAR EWSR1 FAS GRIN1 GRIN2D IL15 IRF1 LTBR MAP2K1 MAP3K14 NGFRAP1 NUP62 OTUD5 PDLIM7 RIPK1 RRAS2 SAR1A SRC TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZMYND11	12 interactors: CCDC155 CDCA7L EMD FATE1 NDEL1 PSTPIP1 SP100 SSSCA1 TFIP11 TRAF3 TRIM36 WAC
Entrez ID		7187	80342
HPRD ID		03539	16305
Ensembl ID		ENSG00000131323	ENSG00000009790
Uniprot IDs		A6NHG8 Q13114	Q9Y228
PDB IDs		1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
Enriched GO Terms of Interacting Partners?		Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Tumor Necrosis Factor Regulation Of Cytokine Production Signal Transduction Positive Regulation Of Protein Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Extrinsic Apoptotic Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Response To Stimulus Immune Response Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Regulation Of Apoptotic Process Response To Cytokine Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Lymphocyte Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Death	Cell Cycle Process Regulation Of Protein Export From Nucleus Nuclear Envelope Disassembly Establishment Of Chromosome Localization Cell Cycle Nuclear Envelope Organization Chromosome Localization To Nuclear Envelope Involved In Synapsis Spliceosomal Complex Disassembly Histone H2B Conserved C-terminal Lysine Ubiquitination Negative Regulation Of Intracellular Protein Transport Regulation Of Fas Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Intracellular Transport Nucleus Organization Organelle Organization Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Axon Regeneration Negative Regulation Of Protein Export From Nucleus Retrograde Axon Cargo Transport Negative Regulation Of Protein Transport Mitotic Cell Cycle Process Intracellular Receptor Signaling Pathway Positive Regulation Of Neuron Projection Regeneration Activation Of Cdc42 GTPase Activity Histone H2B Ubiquitination Mitotic Cell Cycle Regulation Of Nucleocytoplasmic Transport Mitotic Nuclear Envelope Reassembly Mitotic Centrosome Separation Chromosome Segregation Neurofilament Cytoskeleton Organization Innate Immune Response Centrosome Separation Toll Signaling Pathway Negative Regulation Of Catenin Import Into Nucleus Nuclear Envelope Reassembly Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Intracellular Protein Transport DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Axon Regeneration Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Macroautophagy Positive Regulation Of Cdc42 GTPase Activity
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction	amplified approximate blotting construct constructed digested digestion egfp eukaryotic flag fluorescence foundation frame green hek293 inserted kd mononuclear pires2 plasmid precipitation reading restriction sali successfully tag teracting transfected xhoi
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction	amplified approximate blotting construct constructed digested digestion egfp eukaryotic flag fluorescence foundation frame green hek293 inserted kd mononuclear pires2 plasmid precipitation reading restriction sali successfully tag teracting transfected xhoi
Tagcloud (Intersection) ?