NOX4

Gene Name		NADPH oxidase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleolus Mitochondrion Endoplasmic Reticulum Membrane Focal Adhesion Integral Component Of Membrane Apical Plasma Membrane NADPH Oxidase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Electron Carrier Activity NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activity Oxygen Sensor Activity Heme Binding Flavin Adenine Dinucleotide Binding Modified Amino Acid Binding
	Biological Process	Cell Morphogenesis Response To Hypoxia Inflammatory Response Cell Aging Negative Regulation Of Cell Proliferation Positive Regulation Of Smooth Muscle Cell Migration Superoxide Anion Generation Positive Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Bone Resorption Homocysteine Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Oxidation-reduction Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Glucose Stimulus Cellular Response To Gamma Radiation Cellular Response To Transforming Growth Factor Beta Stimulus Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-protein Interactions		1 interactors: TLR4
Entrez ID		50507
HPRD ID		09243
Ensembl ID		ENSG00000086991
Uniprot IDs		B3KQ17 B7Z520 Q9NPH5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Detection Of Fungus Negative Regulation Of Interleukin-23 Production Nitric Oxide Production Involved In Inflammatory Response Detection Of Lipopolysaccharide Intestinal Epithelial Structure Maintenance Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway B Cell Proliferation Involved In Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Platelet Activation Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Interferon-beta Biosynthetic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process I-kappaB Phosphorylation Maintenance Of Gastrointestinal Epithelium Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Tumor Necrosis Factor Biosynthetic Process Interferon-gamma Production Epithelial Structure Maintenance Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Production Of Molecular Mediator Involved In Inflammatory Response T-helper 1 Type Immune Response Detection Of Biotic Stimulus Macrophage Activation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Interleukin-10 Production Regulation Of Platelet Activation Positive Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Blood Coagulation Negative Regulation Of Interferon-gamma Production Defense Response To Gram-negative Bacterium Negative Regulation Of Interleukin-6 Production Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Coagulation Response To Fungus
Tagcloud ?		autophagy cardiomyocytes clarified dedicated deprivation discuss elimination endoplasmic enzymatic exist far ischaemia isoforms minimally modulate nadph nox2 nutrient oxidase past pathogens perk phagocytes regulate representing reticulum ros signalling