TIMP4 and MMP14

Number of citations of the paper that reports this interaction (PMID 11178970)
10

Data Source:
HPRD (in vivo)

		TIMP4	MMP14
Gene Name		TIMP metallopeptidase inhibitor 4	matrix metallopeptidase 14 (membrane-inserted)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Sarcomere	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Melanosome
	Molecular Function	Protease Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Peptidase Activator Activity
	Biological Process	Central Nervous System Development Biological_process Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Lipopolysaccharide Response To Cytokine Response To Drug Ovulation Cycle Response To Peptide Hormone Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis	Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Regulation Of Transcription, DNA-templated Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Peptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Negative Regulation Of Focal Adhesion Assembly Craniofacial Suture Morphogenesis
Pathways			Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MMP14 MMP2	23 interactors: ACAN ADI1 BCAR1 C1QBP CAV1 CCDC155 CCL7 CLDN1 F12 ITGAV KISS1 LRP1 LUM MMP13 MMP2 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP2 TIMP3 TIMP4
Entrez ID		7079	4323
HPRD ID		03557	02856
Ensembl ID		ENSG00000157150	ENSG00000157227
Uniprot IDs		Q99727	P50281
PDB IDs			1BQQ 1BUV 3C7X 3MA2
Enriched GO Terms of Interacting Partners?		Endodermal Cell Differentiation Endoderm Formation Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Formation Of Primary Germ Layer Gastrulation Skeletal System Morphogenesis Ossification Response To Hypoxia Angiogenesis Extracellular Matrix Organization Extracellular Structure Organization Blood Vessel Morphogenesis Blood Vessel Development Vasculature Development Skeletal System Development Astrocyte Cell Migration Intramembranous Ossification Chondrocyte Proliferation Embryonic Morphogenesis Bone Trabecula Formation Blood Vessel Maturation Craniofacial Suture Morphogenesis Cardiovascular System Development Bone Trabecula Morphogenesis Endothelial Cell Proliferation Negative Regulation Of Focal Adhesion Assembly Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Response To Abiotic Stimulus Embryo Development Single Organism Reproductive Process Locomotion Face Morphogenesis Negative Regulation Of Cell-matrix Adhesion Reproductive Process Head Morphogenesis Endochondral Ossification Regulation Of Focal Adhesion Assembly Trabecula Morphogenesis Movement Of Cell Or Subcellular Component Face Development Proteolysis Negative Regulation Of Cell-substrate Adhesion Body Morphogenesis Regulation Of Cell Junction Assembly	Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Protein Processing Regulation Of Peptidase Activity Extracellular Matrix Disassembly Response To Wounding Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Sulfur Compound Metabolic Process Wound Healing Negative Regulation Of Proteolysis Response To Stimulus Glycosaminoglycan Catabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Processing System Development Anatomical Structure Development Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Cellular Component Movement Blood Coagulation Hemostasis Keratan Sulfate Catabolic Process Response To Organic Substance Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Protein Metabolic Process Multicellular Organismal Development Blood Coagulation, Intrinsic Pathway Glycosaminoglycan Biosynthetic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Proteoglycan Metabolic Process Response To External Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Cell Migration Response To Hormone Positive Regulation Of Cell Migration Keratan Sulfate Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Keratan Sulfate Metabolic Process
Tagcloud ?		6v3 akr1c2 amongst appearing bard1 beadchip bisulfite cdf15 cobra coro2a cyrillic5 diagnostics dnajc12 hook1 humanwd illumina interrogated normalcy ntrk4 pppqr1b s100p sentrix sfrp1 tff1 top2a tp53ink1 tusc5 tuscapital unmethylated	5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Difference) ?		6v3 akr1c2 amongst appearing bard1 beadchip bisulfite cdf15 cobra coro2a cyrillic5 dnajc12 hook1 humanwd illumina interrogated normalcy ntrk4 pppqr1b s100p sentrix sfrp1 tff1 top2a tp53ink1 tusc5 tuscapital unmethylated	5p analyze differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Intersection) ?		diagnostics