MMP14 and ADI1

Number of citations of the paper that reports this interaction (PMID 14718544)
12

Data Source:
HPRD (in vitro, two hybrid)

		MMP14	ADI1
Gene Name		matrix metallopeptidase 14 (membrane-inserted)	acireductone dioxygenase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Melanosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Peptidase Activator Activity	Iron Ion Binding Protein Binding Acireductone Dioxygenase [iron(II)-requiring] Activity Oxidoreductase Activity
	Biological Process	Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Regulation Of Transcription, DNA-templated Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Peptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Negative Regulation Of Focal Adhesion Assembly Craniofacial Suture Morphogenesis	Sulfur Amino Acid Metabolic Process Polyamine Metabolic Process L-methionine Biosynthetic Process From Methylthioadenosine Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Metabolism of polyamines Sulfur amino acid metabolism Methionine salvage pathway Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ACAN ADI1 BCAR1 C1QBP CAV1 CCDC155 CCL7 CLDN1 F12 ITGAV KISS1 LRP1 LUM MMP13 MMP2 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP2 TIMP3 TIMP4	2 interactors: APP MMP14
Entrez ID		4323	55256
HPRD ID		02856	17607
Ensembl ID		ENSG00000157227	ENSG00000182551
Uniprot IDs		P50281	Q9BV57
PDB IDs		1BQQ 1BUV 3C7X 3MA2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Protein Processing Regulation Of Peptidase Activity Extracellular Matrix Disassembly Response To Wounding Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Sulfur Compound Metabolic Process Wound Healing Negative Regulation Of Proteolysis Response To Stimulus Glycosaminoglycan Catabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Processing System Development Anatomical Structure Development Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Cellular Component Movement Blood Coagulation Hemostasis Keratan Sulfate Catabolic Process Response To Organic Substance Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Protein Metabolic Process Multicellular Organismal Development Blood Coagulation, Intrinsic Pathway Glycosaminoglycan Biosynthetic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Proteoglycan Metabolic Process Response To External Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Cell Migration Response To Hormone Positive Regulation Of Cell Migration Keratan Sulfate Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Keratan Sulfate Metabolic Process	Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Positive Regulation Of Proteolysis Collateral Sprouting In Absence Of Injury Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Response To Oxidative Stress Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Astrocyte Cell Migration Regulation Of Growth Neuron Remodeling Chondrocyte Proliferation Regulation Of Proteolysis Craniofacial Suture Morphogenesis Endothelial Cell Proliferation Cellular Copper Ion Homeostasis Negative Regulation Of Focal Adhesion Assembly Copper Ion Homeostasis Suckling Behavior Positive Regulation Of Hydrolase Activity Reproduction Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Metabolic Process Mating Behavior Locomotion Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Endodermal Cell Differentiation Negative Regulation Of Cell-matrix Adhesion Reproductive Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Endochondral Ossification Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Focal Adhesion Assembly Regulation Of Cell Cycle G2/M Phase Transition Movement Of Cell Or Subcellular Component Positive Regulation Of Catalytic Activity Negative Regulation Of Cell-substrate Adhesion Axon Cargo Transport
Tagcloud ?		5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Difference) ?		5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Intersection) ?