TIMP2 and MMP14

Number of citations of the paper that reports this interaction (PMID 9724659)
41

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		TIMP2	MMP14
Gene Name		TIMP metallopeptidase inhibitor 2	matrix metallopeptidase 14 (membrane-inserted)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Cell Surface Growth Cone Neuronal Cell Body Extracellular Vesicular Exosome	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Melanosome
	Molecular Function	Protease Binding Integrin Binding Protein Binding Enzyme Activator Activity Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Peptidase Activator Activity
	Biological Process	Central Nervous System Development Aging Negative Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Regulation Of Rap Protein Signal Transduction Response To Cytokine Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Organic Substance	Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Regulation Of Transcription, DNA-templated Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Peptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Negative Regulation Of Focal Adhesion Assembly Craniofacial Suture Morphogenesis
Pathways		Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: ITGA3 ITGB1 MMP14 MMP2 MMP8	23 interactors: ACAN ADI1 BCAR1 C1QBP CAV1 CCDC155 CCL7 CLDN1 F12 ITGAV KISS1 LRP1 LUM MMP13 MMP2 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP2 TIMP3 TIMP4
Entrez ID		7077	4323
HPRD ID		01784	02856
Ensembl ID		ENSG00000035862	ENSG00000157227
Uniprot IDs		P16035	P50281
PDB IDs		1BR9 1GXD 2TMP	1BQQ 1BUV 3C7X 3MA2
Enriched GO Terms of Interacting Partners?		Formation Of Primary Germ Layer Gastrulation Extracellular Matrix Organization Extracellular Structure Organization Embryonic Morphogenesis Endodermal Cell Differentiation Endoderm Formation Collagen Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Embryo Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Tissue Development Negative Regulation Of Rho Protein Signal Transduction Regulation Of Cell-substrate Adhesion Cardiovascular System Development Female Pregnancy Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Anatomical Structure Morphogenesis Mesodermal Cell Differentiation Response To Gonadotropin Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Locomotion Single Organism Reproductive Process Locomotion Reproductive Process Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Blood Vessel Morphogenesis Cell Differentiation Movement Of Cell Or Subcellular Component Blood Vessel Development Maternal Process Involved In Female Pregnancy Vasculature Development Neurogenesis Mesoderm Formation Regulation Of Cell Migration Mesoderm Morphogenesis Regulation Of Cell Adhesion Regulation Of Cell Motility Tissue Morphogenesis	Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Protein Processing Regulation Of Peptidase Activity Extracellular Matrix Disassembly Response To Wounding Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Sulfur Compound Metabolic Process Wound Healing Negative Regulation Of Proteolysis Response To Stimulus Glycosaminoglycan Catabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Processing System Development Anatomical Structure Development Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Cellular Component Movement Blood Coagulation Hemostasis Keratan Sulfate Catabolic Process Response To Organic Substance Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Protein Metabolic Process Multicellular Organismal Development Blood Coagulation, Intrinsic Pathway Glycosaminoglycan Biosynthetic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Proteoglycan Metabolic Process Response To External Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Cell Migration Response To Hormone Positive Regulation Of Cell Migration Keratan Sulfate Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Keratan Sulfate Metabolic Process
Tagcloud ?		achn acquired analyze bo5 bone determinants elucidate elucidated enhancer ex explore ezh2 homolog immunohistochemical metalloproteinase metastasis metastasized methylated methylation mmp2 newly parental rcc specimens subline tissues underlying upregulation zeste	5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Difference) ?		achn acquired bo5 bone determinants elucidate elucidated enhancer ex explore ezh2 homolog immunohistochemical metastasis metastasized methylated methylation mmp2 newly parental rcc specimens subline underlying upregulation zeste	5p diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses validated worldwide
Tagcloud (Intersection) ?		analyze metalloproteinase tissues