TGFBI and COL4A4

Number of citations of the paper that reports this interaction (PMID 11867580)
19

Data Source:
HPRD (in vitro)

		TGFBI	COL4A4
Gene Name		transforming growth factor, beta-induced, 68kDa	collagen, type IV, alpha 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Trans-Golgi Network Plasma Membrane Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Collagen Type IV Trimer Basal Lamina Endoplasmic Reticulum Lumen
	Molecular Function	Integrin Binding Protein Binding Collagen Binding Extracellular Matrix Binding	Extracellular Matrix Structural Constituent
	Biological Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Visual Perception Cell Proliferation Extracellular Matrix Organization Response To Stimulus	Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Glomerular Basement Membrane Development
Pathways		Amyloids	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		10 interactors: A2M COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 FAM9B FN1	12 interactors: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 TGFBI
Entrez ID		7045	1286
HPRD ID		03409	00360
Ensembl ID		ENSG00000120708	ENSG00000081052
Uniprot IDs		Q15582	P53420
PDB IDs		1X3B 2LTB 2VXP
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Axon Guidance Cardiovascular System Development Catabolic Process Platelet Activation Blood Vessel Development Cell Morphogenesis Axonogenesis Vasculature Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Cell Differentiation Neuron Projection Morphogenesis Developmental Process Vesicle-mediated Transport Neuron Projection Development Receptor-mediated Endocytosis Generation Of Neurons Cell Projection Morphogenesis Cell Part Morphogenesis System Development Protein Heterotrimerization Neurogenesis Response To Amino Acid Blood Coagulation Neuron Development Hemostasis Cell Development Response To External Stimulus Glomerular Basement Membrane Development Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Sensory Perception Of Sound Anatomical Structure Development Neuron Differentiation Cell Projection Organization Cellular Response To Acid Chemical	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Response To Wounding Wound Healing Endodermal Cell Differentiation Acute-phase Response Leukocyte Migration Regulation Of Cell Adhesion Peptide Cross-linking Endoderm Formation Seminal Vesicle Epithelium Development Dendrite Regeneration Anatomical Structure Morphogenesis Cell Migration Acute Inflammatory Response Cell Motility Endoderm Development Negative Regulation Of Transport Tissue Development Negative Regulation Of Ion Transport Mating Plug Formation Blood Coagulation Hemostasis Response To External Stimulus Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein System Development Formation Of Primary Germ Layer Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Receptor Binding Calcium-independent Cell-matrix Adhesion Cell Adhesion Positive Regulation Of Keratinocyte Migration Negative Regulation Of Plasminogen Activation Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Body Fluid Levels Locomotion Immune System Process Chemotaxis Regulation Of Growth Reproductive Process Nervous System Development Multicellular Organismal Development Response To Stress Gastrulation Platelet Activation Cell Activation Negative Regulation Of Platelet Aggregation Tyrosine Phosphorylation Of STAT Protein
Tagcloud ?		alignment arrangements articular bigh3 biglycan cartilage chondrocytic collagen collagens crossing decorin forming healing heterozygous knockout maintaining matrix metalloproteinase mineral mmp13 plates preparation safranin skeletal smaller transforming trichrome tumorigenesis wound	alport basement clarification classic diagnostics families focal fsgs gbm glomerulosclerosis hematuria hereditary heterozygous histologic illustrates inconsistent inherited interpretation nephritis nephropathy nephrotic pathognomonic predominant proteinuria segmental segregated thin variants
Tagcloud (Difference) ?		alignment arrangements articular bigh3 biglycan cartilage chondrocytic collagen collagens crossing decorin forming healing knockout maintaining matrix metalloproteinase mineral mmp13 plates preparation safranin skeletal smaller transforming trichrome tumorigenesis wound	alport basement clarification classic diagnostics families focal fsgs gbm glomerulosclerosis hematuria hereditary histologic illustrates inconsistent inherited interpretation nephritis nephropathy nephrotic pathognomonic predominant proteinuria segmental segregated thin variants
Tagcloud (Intersection) ?		heterozygous