TGFBI and COL4A1

Number of citations of the paper that reports this interaction (PMID 11867580)
19

Data Source:
HPRD (in vitro)

		TGFBI	COL4A1
Gene Name		transforming growth factor, beta-induced, 68kDa	collagen, type IV, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Trans-Golgi Network Plasma Membrane Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Integrin Binding Protein Binding Collagen Binding Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Platelet-derived Growth Factor Binding
	Biological Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Visual Perception Cell Proliferation Extracellular Matrix Organization Response To Stimulus	Patterning Of Blood Vessels Receptor-mediated Endocytosis Axon Guidance Brain Development Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization
Pathways		Amyloids	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS			Arterial stiffness ( 20031579) Coronary heart disease ( 21378990) Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: A2M COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 FAM9B FN1	27 interactors: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1
Entrez ID		7045	1282
HPRD ID		03409	00359
Ensembl ID		ENSG00000120708	ENSG00000187498
Uniprot IDs		Q15582	P02462
PDB IDs		1X3B 2LTB 2VXP	1LI1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Axon Guidance Cardiovascular System Development Catabolic Process Platelet Activation Blood Vessel Development Cell Morphogenesis Axonogenesis Vasculature Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Cell Differentiation Neuron Projection Morphogenesis Developmental Process Vesicle-mediated Transport Neuron Projection Development Receptor-mediated Endocytosis Generation Of Neurons Cell Projection Morphogenesis Cell Part Morphogenesis System Development Protein Heterotrimerization Neurogenesis Response To Amino Acid Blood Coagulation Neuron Development Hemostasis Cell Development Response To External Stimulus Glomerular Basement Membrane Development Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Sensory Perception Of Sound Anatomical Structure Development Neuron Differentiation Cell Projection Organization Cellular Response To Acid Chemical	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Wound Healing Acute-phase Response Extracellular Matrix Disassembly Tissue Development Blood Coagulation Platelet Degranulation Hemostasis Acute Inflammatory Response Multicellular Organismal Development System Development Cell Adhesion Anatomical Structure Development Locomotion Platelet Activation Response To Stress Endodermal Cell Differentiation Regulation Of Body Fluid Levels Developmental Process Formation Of Primary Germ Layer Regulation Of Wound Healing Inflammatory Response Endoderm Formation Anatomical Structure Morphogenesis Negative Regulation Of Platelet Activation Negative Regulation Of Wound Healing Organ Development Defense Response Negative Regulation Of Phosphatidylinositol Biosynthetic Process Gastrulation Cell Migration Movement Of Cell Or Subcellular Component Endoderm Development Chemotaxis Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cell Differentiation Regulation Of Blood Coagulation Regulation Of Platelet Activation Cell Motility Response To Stimulus Leukocyte Migration Connective Tissue Development Blood Vessel Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Cell Activation Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?		alignment arrangements articular bigh3 biglycan cartilage chondrocytic collagen collagens crossing decorin forming healing heterozygous knockout maintaining matrix metalloproteinase mineral mmp13 plates preparation safranin skeletal smaller transforming trichrome tumorigenesis wound	arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white
Tagcloud (Difference) ?		alignment arrangements articular bigh3 biglycan cartilage chondrocytic collagen collagens crossing decorin forming healing heterozygous knockout maintaining matrix metalloproteinase mineral mmp13 plates preparation safranin skeletal smaller transforming trichrome tumorigenesis wound	arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white
Tagcloud (Intersection) ?