TCF7L2 and CSNK2A2

Number of citations of the paper that reports this interaction (PMID 11711551)
28

Data Source:
HPRD (in vitro)

		TCF7L2	CSNK2A2
Gene Name		transcription factor 7-like 2 (T-cell specific, HMG-box)	casein kinase 2, alpha prime polypeptide
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex	Nucleus Cytosol PcG Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding Nuclear Hormone Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Glycogen Metabolic Process Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Brain Development Cell Proliferation Cellular Response To Starvation Response To Glucose Post-embryonic Development Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Oligodendrocyte Development Neural Tube Development Pituitary Gland Development Bone Mineralization Negative Regulation Of BMP Signaling Pathway Embryonic Genitalia Morphogenesis Pancreas Development Regulation Of Myelination Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Binding Secretory Granule Localization Regulation Of Hormone Metabolic Process Somatic Stem Cell Maintenance Multicellular Organism Growth Catenin Import Into Nucleus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Maintenance Of DNA Repeat Elements Skin Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Organ Growth Positive Regulation Of Protein Export From Nucleus Embryonic Digestive Tract Morphogenesis Embryonic Hindgut Morphogenesis Myoblast Fate Commitment Regulation Of Skeletal Muscle Tissue Development Regulation Of Smooth Muscle Cell Proliferation Generation Of Neurons Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Face Morphogenesis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Insulin Metabolic Process Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Axon Guidance Wnt Signaling Pathway Mitotic Spindle Checkpoint
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Peptide hormone metabolism Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Incretin synthesis, secretion, and inactivation truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast Cancer in BRCA1 mutation carriers ( 23544013) Coronary heart disease ( 21347282) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting insulin-related traits (interaction with BMI) ( 22581228) Glycated hemoglobin levels ( 20849430) Metabolic syndrome ( 20694148) Proinsulin levels ( 21873549) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 17668382 18372903 17293876 22693455 17554300 23300278 20581827 19401414 17463246 17463248 17463249 22101970 17460697 19056611 23209189) Type 2 diabetes and other traits ( 19734900)
Protein-Protein Interactions		13 interactors: CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CTNNBIP1 DAXX DAZAP2 EP300 FBLN1 JUP PSEN1 PSMA3 UBE2I	92 interactors: ABCA1 ACACA ADH1A AQP4 ARR3 ARRB2 ASL ATF1 ATF2 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERH FGF1 FGF2 FKBP3 FOS GTF2A1 GTF2A1L HDAC1 HDAC2 HDAC6 HIST1H1C HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 JUN KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL P4HB PAK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3
Entrez ID		6934	1459
HPRD ID		03751	00279
Ensembl ID		ENSG00000148737	ENSG00000070770
Uniprot IDs		B4DJZ2 B4DRJ8 B7Z9Z6 B9X074 C6ZRJ7 C6ZRJ8 C6ZRJ9 C6ZRK0 C6ZRK1 C6ZRK2 C6ZRK5 E2GH13 E2GH14 E2GH16 E2GH18 E2GH24 E2GH25 E2GH26 Q6FHW4 Q9NQB0	P19784
PDB IDs		1JDH 1JPW 2GL7	3E3B 3OFM 3U87
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Viral Process Apoptotic Process Wnt Signaling Pathway Programmed Cell Death Cell Cycle Process Cell Death Death Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Mitotic Cell Cycle Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Cellular Response To Indole-3-methanol Regulation Of Chromosome Organization Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Anterior/posterior Pattern Specification Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process	Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Abiotic Stimulus Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Stimulus Regulation Of Gene Expression Developmental Process Innate Immune Response Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune System Process Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus Immune Response-regulating Signaling Pathway Cellular Response To Stress Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Response To Organic Cyclic Compound Regulation Of Signaling Transcription, DNA-templated Regulation Of Phosphorus Metabolic Process Gene Expression Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Immune Response Regulation Of Phosphorylation Cell Differentiation Negative Regulation Of Signal Transduction Anatomical Structure Development Nitrogen Compound Metabolic Process Multicellular Organismal Development Defense Response Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression
Tagcloud ?		3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite pck1 picture preferential pyruvate redundant repressive suppressing views wnt	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Difference) ?		3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite pck1 picture preferential pyruvate redundant repressive suppressing views wnt	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Intersection) ?