CSNK2A2 and EIF2B5

Number of citations of the paper that reports this interaction (PMID 11500362)
28

Data Source:
HPRD (in vitro, in vivo)

		CSNK2A2	EIF2B5
Gene Name		casein kinase 2, alpha prime polypeptide	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol PcG Protein Complex	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Axon Guidance Wnt Signaling Pathway Mitotic Spindle Checkpoint	Ovarian Follicle Development Translation Translational Initiation Response To Heat Response To Glucose Gene Expression Astrocyte Development Oligodendrocyte Development Negative Regulation Of Translational Initiation In Response To Stress Response To Endoplasmic Reticulum Stress Cellular Response To Drug Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Astrocyte Differentiation
Pathways		Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes	Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		92 interactors: ABCA1 ACACA ADH1A AQP4 ARR3 ARRB2 ASL ATF1 ATF2 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERH FGF1 FGF2 FKBP3 FOS GTF2A1 GTF2A1L HDAC1 HDAC2 HDAC6 HIST1H1C HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 JUN KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL P4HB PAK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3	11 interactors: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 EIF2B1 EIF2B2 EIF2B4 EIF2S2 GSK3A GSK3B
Entrez ID		1459	8893
HPRD ID		00279	04898
Ensembl ID		ENSG00000070770	ENSG00000145191
Uniprot IDs		P19784	Q13144
PDB IDs		3E3B 3OFM 3U87	3JUI
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Abiotic Stimulus Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Stimulus Regulation Of Gene Expression Developmental Process Innate Immune Response Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune System Process Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus Immune Response-regulating Signaling Pathway Cellular Response To Stress Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Response To Organic Cyclic Compound Regulation Of Signaling Transcription, DNA-templated Regulation Of Phosphorus Metabolic Process Gene Expression Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Immune Response Regulation Of Phosphorylation Cell Differentiation Negative Regulation Of Signal Transduction Anatomical Structure Development Nitrogen Compound Metabolic Process Multicellular Organismal Development Defense Response Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression	Wnt Signaling Pathway Response To Heat Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Oligodendrocyte Development Nervous System Development Hypermethylation Of CpG Island Negative Regulation Of Protein Metabolic Process Response To Temperature Stimulus Cellular Response To Interleukin-3 Neurogenesis Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Hydrolase Activity Translational Initiation Negative Regulation Of Glycogen (starch) Synthase Activity Cell Development Protein Metabolic Process Regulation Of Translational Initiation Regulation Of Translation Negative Regulation Of Translation In Response To Stress Oligodendrocyte Differentiation System Development Regulation Of Wnt Signaling Pathway Rhythmic Process Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cellular Metabolic Process Protein Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Glial Cell Development Multicellular Organismal Development Regulation Of Type B Pancreatic Cell Development Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Mitotic Nuclear Division Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Translation In Response To Stress Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Anatomical Structure Development Regulation Of Mitotic Cell Cycle Response To Glucose Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Negative Regulation Of Translational Initiation
Tagcloud ?		bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis	1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm
Tagcloud (Difference) ?		bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis	1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm
Tagcloud (Intersection) ?