SYP and AP1G1

Number of citations of the paper that reports this interaction (PMID 12498786)
9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		SYP	AP1G1
Gene Name		synaptophysin	adaptor-related protein complex 1, gamma 1 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptic Vesicle Cell Junction Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Presynaptic Membrane Neuron Projection Protein Complex Neuron Projection Terminus Presynaptic Active Zone Excitatory Synapse	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-type Membrane Coat Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Transporter Activity Cholesterol Binding Syntaxin-1 Binding Protein Complex Binding SH2 Domain Binding Identical Protein Binding Protein Self-association	Transporter Activity Protein Binding Protein Transporter Activity Rab GTPase Binding Kinesin Binding GTP-dependent Protein Binding
	Biological Process	Endocytosis Synaptic Vesicle Maturation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Membrane Organization Cellular Response To Organic Substance Regulation Of Opioid Receptor Signaling Pathway	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Membrane Organization Golgi To Lysosome Transport
Pathways			Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: AP1G1 EPOR GRB2 SIAH1 SIAH2 VAMP2	20 interactors: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 CLINT1 CLTC DNER KIF13A MAP1A RAB5A RABEP1 RABGEF1 SPTB SYNRG SYP UBL7 ZNF512B
Entrez ID		6855	164
HPRD ID		02435	04637
Ensembl ID		ENSG00000102003	ENSG00000166747
Uniprot IDs		B7Z359 P08247	O43747 Q8IY97
PDB IDs			1IU1
Enriched GO Terms of Interacting Partners?		Axon Guidance Post-Golgi Vesicle-mediated Transport Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Response To External Stimulus Erythropoietin-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Degranulation Cell Morphogenesis Involved In Differentiation Regulation Of Exocytosis Golgi To Lysosome Transport Eosinophil Degranulation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cellular Response To Erythropoietin Placenta Development Nervous System Development Vesicle Organization Cellular Response To Insulin Stimulus Neuron Development Cell Morphogenesis Response To Stimulus Golgi Vesicle Transport Golgi To Vacuole Transport Neuron Differentiation Cell Projection Organization Pigment Granule Maturation Endosome To Melanosome Transport Response To Insulin Single Organism Reproductive Process Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Pigment Accumulation Branching Involved In Labyrinthine Layer Morphogenesis Locomotion Cellular Response To Peptide Reproductive Process Developmental Process Regulation Of Signaling Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Regulation Of Lymphocyte Activation Movement Of Cell Or Subcellular Component Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Generation Of Neurons Cell Differentiation Positive Regulation Of Regulated Secretory Pathway	Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Regulation Of Defense Response To Virus By Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Localization Intracellular Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Localization In Cell Endocytosis Cellular Localization Regulation Of Defense Response To Virus Transport Establishment Of Vesicle Localization Intracellular Protein Transport Vesicle Localization Cellular Protein Localization Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Establishment Of Organelle Localization Organelle Localization Vesicle Targeting Vesicle Organization Viral Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Vesicle Targeting, To, From Or Within Golgi Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Immune System Process Regulation Of Endocytosis Synaptic Vesicle Recycling Receptor Internalization Endosomal Transport Negative Regulation Of Kit Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Immune System Process Vesicle Targeting, Trans-Golgi To Endosome Synaptic Vesicle Membrane Organization Regulation Of Synaptic Transmission Membrane Budding Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Endosome Size Regulation Of Opioid Receptor Signaling Pathway
Tagcloud ?		2h3 accessory aggregation associate coprecipitated dephosphorylated epsilonri fc homology ige immunoreceptor mast phosphatases phosphorylated precipitated ptp1 ptp1c ptp1d ptp2 ptp2c rbl reciprocal sh shp src syk synthetic tyrosine unlike
Tagcloud (Difference) ?		2h3 accessory aggregation associate coprecipitated dephosphorylated epsilonri fc homology ige immunoreceptor mast phosphatases phosphorylated precipitated ptp1 ptp1c ptp1d ptp2 ptp2c rbl reciprocal sh shp src syk synthetic tyrosine unlike
Tagcloud (Intersection) ?