AP1G1 and SYNRG

Number of citations of the paper that reports this interaction (PMID 10814529)
30

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		AP1G1	SYNRG
Gene Name		adaptor-related protein complex 1, gamma 1 subunit	synergin, gamma
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-type Membrane Coat Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome	Cytoplasm Golgi Apparatus AP-1 Adaptor Complex
	Molecular Function	Transporter Activity Protein Binding Protein Transporter Activity Rab GTPase Binding Kinesin Binding GTP-dependent Protein Binding
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Membrane Organization Golgi To Lysosome Transport	Intracellular Protein Transport Endocytosis
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS			Ovarian cancer ( 23535730) Response to angiotensin II receptor blocker therapy ( 22566498)
Protein-Protein Interactions		20 interactors: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 CLINT1 CLTC DNER KIF13A MAP1A RAB5A RABEP1 RABGEF1 SPTB SYNRG SYP UBL7 ZNF512B	8 interactors: AP1G1 AP1G2 APPBP2 CCDC91 GGA1 GGA2 GGA3 SCAMP1
Entrez ID		164	11276
HPRD ID		04637	06291
Ensembl ID		ENSG00000166747	ENSG00000006114
Uniprot IDs		O43747 Q8IY97	A8MWU4 Q9UMZ2
PDB IDs		1IU1
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Regulation Of Defense Response To Virus By Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Localization Intracellular Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Localization In Cell Endocytosis Cellular Localization Regulation Of Defense Response To Virus Transport Establishment Of Vesicle Localization Intracellular Protein Transport Vesicle Localization Cellular Protein Localization Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Establishment Of Organelle Localization Organelle Localization Vesicle Targeting Vesicle Organization Viral Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Vesicle Targeting, To, From Or Within Golgi Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Immune System Process Regulation Of Endocytosis Synaptic Vesicle Recycling Receptor Internalization Endosomal Transport Negative Regulation Of Kit Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Immune System Process Vesicle Targeting, Trans-Golgi To Endosome Synaptic Vesicle Membrane Organization Regulation Of Synaptic Transmission Membrane Budding Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Endosome Size Regulation Of Opioid Receptor Signaling Pathway	Protein Transport Establishment Of Protein Localization Protein Localization Intracellular Transport Intracellular Protein Transport Establishment Of Localization In Cell Cellular Protein Localization Cellular Localization Vesicle-mediated Transport Transport Post-Golgi Vesicle-mediated Transport Positive Regulation Of Natural Killer Cell Degranulation Golgi To Lysosome Transport Positive Regulation Of Protein Catabolic Process Golgi To Vacuole Transport Endosome To Melanosome Transport Pigment Granule Maturation Golgi Vesicle Transport Cellular Pigment Accumulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Protein Catabolic Process Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Regulated Secretory Pathway Melanosome Organization Pigment Granule Organization Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Natural Killer Cell Activation Regulation Of Regulated Secretory Pathway Viral Process Lysosomal Transport Cellular Pigmentation Positive Regulation Of Exocytosis Developmental Pigmentation
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