SULT1E1 and SETDB1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SULT1E1	SETDB1
Gene Name		sulfotransferase family 1E, estrogen-preferring, member 1	SET domain, bifurcated 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Estrone Sulfotransferase Activity Steroid Binding Flavonol 3-sulfotransferase Activity Steroid Sulfotransferase Activity	DNA Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity
	Biological Process	Xenobiotic Metabolic Process Female Pregnancy Steroid Metabolic Process Estrogen Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Inner Cell Mass Cell Proliferation Chromatin Organization Transcription, DNA-templated Histone H3-K9 Trimethylation Bone Development
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Cytosolic sulfonation of small molecules Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs		Cyclizine Adenosine-3\'-5\'-Diphosphate 3\'-Phosphate-Adenosine-5\'-Phosphate Sulfate 3,5,3\',5\'-Tetrachloro-Biphenyl-4,4\'-Diol
Diseases
GWAS			Chronic kidney disease ( 20383146) Melanoma ( 21983785)
Protein-Protein Interactions		13 interactors: BMPR2 C14orf1 COPS6 EEF1A1 ENOX1 IGSF21 LRIF1 PDE9A RBM48 SETDB1 SULT2B1 TP53 UNC119	107 interactors: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 C11orf1 CBX8 CCDC106 CDK4 CDKN1A CLSTN1 CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 HDAC1 HDAC2 HIST1H3A HIST2H3A HIST3H3 HIST4H4 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPARG PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VIM ZFP64 ZNF24
Entrez ID		6783	9869
HPRD ID		08966	06828
Ensembl ID		ENSG00000109193	ENSG00000143379
Uniprot IDs		P49888 Q53X91	Q15047
PDB IDs		1G3M 1HY3 4JVL 4JVM 4JVN	3DLM
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Methylation Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Chromosome Organization Regulation Of RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of Proteolysis DNA Modification Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Response To Stress Transcription, DNA-templated Gene Silencing Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Chromatin Silencing Metabolic Process RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Cell Cycle
Tagcloud ?		analyzing bovine caruncular catalyzed conflict conflicting esr esrs estrogens expresses giant placentas pools posttranscriptional produces resolve sorting sulfonation tgc tgcs transcript trophoblast unable uninucleated utc utcs virtually	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified
Tagcloud (Difference) ?		analyzing bovine caruncular catalyzed conflict conflicting esr esrs estrogens expresses giant placentas pools posttranscriptional produces resolve sorting sulfonation tgc tgcs transcript trophoblast unable uninucleated utc utcs virtually	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified
Tagcloud (Intersection) ?