SSRP1 and RAN

Number of citations of the paper that reports this interaction (PMID 12101123)
41

Data Source:
HPRD (in vivo, in vitro)

		SSRP1	RAN
Gene Name		structure specific recognition protein 1	RAN, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm	Chromatin Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Melanosome Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding	Chromatin Binding Transcription Coactivator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Poly(A) RNA Binding Androgen Receptor Binding
	Biological Process	DNA Replication DNA Repair Chromatin Remodeling Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of Viral Transcription	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus DNA Metabolic Process Protein Import Into Nucleus Protein Export From Nucleus Mitotic Spindle Organization Mitotic Nuclear Division Signal Transduction Small GTPase Mediated Signal Transduction Spermatid Development Gene Expression Viral Process Viral Life Cycle Actin Cytoskeleton Organization Androgen Receptor Signaling Pathway Positive Regulation Of Protein Binding Cellular Protein Complex Localization Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Division Intracellular Transport Of Virus
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Transcriptional regulation by small RNAs Metabolism of lipids and lipoproteins Nuclear import of Rev protein HIV Infection Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Host Interactions of HIV factors MicroRNA (miRNA) biogenesis Influenza Infection Interactions of Rev with host cellular proteins Late Phase of HIV Life Cycle Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Export of Viral Ribonucleoproteins from Nucleus HIV Life Cycle Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H2AFX H3F3A HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE MCM4 MYCBP NEK9 RAN ROBO2 SPI1 SREK1 SRF SUMO1	55 interactors: ABL1 ADRB2 AR ASAP2 BCAR1 BMPR1B CSE1L EP300 GADD45G GIT1 IPO11 IPO13 IPO5 IPO7 KIAA1377 KPNA2 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUPR1 NUTF2 NXF1 NXT1 PAK4 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SNUPN SPAG8 SSRP1 TGFBR1 TNPO1 TNPO2 XPO1 XPO4 XPO5 XPO7 XPOT
Entrez ID		6749	5901
HPRD ID		05061	03109
Ensembl ID		ENSG00000149136
Uniprot IDs		Q08945	B4DV51 P62826
PDB IDs			1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4
Enriched GO Terms of Interacting Partners?		DNA Conformation Change Chromosome Organization Organelle Organization Nucleosome Assembly Chromatin Assembly Nucleobase-containing Compound Metabolic Process Nucleosome Organization DNA Methylation On Cytosine Chromatin Assembly Or Disassembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein-DNA Complex Assembly Chromatin Silencing At RDNA Cellular Nitrogen Compound Metabolic Process DNA Packaging Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Nitrogen Compound Metabolic Process Chromatin Silencing Gene Expression DNA Metabolic Process DNA Methylation Mitotic Cell Cycle DNA Replication-dependent Nucleosome Assembly DNA Duplex Unwinding DNA Geometric Change DNA Modification Cell Cycle Gene Silencing Regulation Of Gene Expression Positive Regulation Of Cell Growth Nucleus Organization Cellular Macromolecular Complex Assembly Cell Cycle Process Mitotic Cell Cycle Process Apoptotic Process Involved In Development DNA Replication-independent Nucleosome Assembly Olfactory Bulb Development Regulation Of Cellular Component Organization Olfactory Lobe Development Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Patterning Of Blood Vessels Positive Regulation Of Growth Contractile Actin Filament Bundle Assembly Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Nucleocytoplasmic Transport Nuclear Transport Cytoplasmic Transport Intracellular Transport Protein Transport Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Nuclear Import Protein Localization Cellular Localization Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cellular Protein Localization Protein Import Establishment Of Protein Localization To Organelle RNA Transport RNA Localization Protein Localization To Organelle Protein Targeting Protein Export From Nucleus Nuclear Export Transport Ribosomal Protein Import Into Nucleus Positive Regulation Of Ran GTPase Activity Viral Life Cycle MRNA Transport Cellular Response To Organic Substance Mitotic Cell Cycle Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly NLS-bearing Protein Import Into Nucleus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Organic Substance Regulation Of Nucleocytoplasmic Transport Cell Cycle Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Process Nuclear Envelope Organization Mitotic Cell Cycle Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Export From Nucleus Intracellular Transport Of Virus Regulation Of Intracellular Transport Cellular Response To Transforming Growth Factor Beta Stimulus Viral Transcription
Tagcloud ?		coordinates cryptic displacement facilitates fact h2b h3k36me3 hypb intragenic kmt3a lys36 mammals methyltransferase modulates nucleosome nucleosomes observe occupancy positioned prevents recruitment repressing set2 setd2 spt16 spurious templates termed trimethylated	5a accessible actually arginine bandshift bi cargo characterised directional dissociated export exports gtpase heterodimer import imported importin localisation masks multimeric nes nls nucleoplasm overlaps rab rev rip shuttle unspliced
Tagcloud (Difference) ?		coordinates cryptic displacement facilitates fact h2b h3k36me3 hypb intragenic kmt3a lys36 mammals methyltransferase modulates nucleosome nucleosomes observe occupancy positioned prevents recruitment repressing set2 setd2 spt16 spurious templates termed trimethylated	5a accessible actually arginine bandshift bi cargo characterised directional dissociated export exports gtpase heterodimer import imported importin localisation masks multimeric nes nls nucleoplasm overlaps rab rev rip shuttle unspliced
Tagcloud (Intersection) ?