SPR and CAMK2G

Number of citations of the paper that reports this interaction (PMID 11825621)
0

Data Source:
HPRD (in vitro)

		SPR	CAMK2G
Gene Name		sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)	calcium/calmodulin-dependent protein kinase II gamma
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Nucleoplasm Cytosol Plasma Membrane Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	Aldo-keto Reductase (NADP) Activity Sepiapterin Reductase Activity NADP Binding	Calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Protein Homodimerization Activity
	Biological Process	L-phenylalanine Metabolic Process Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Death Pteridine Metabolic Process Regulation Of Multicellular Organism Growth Norepinephrine Metabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Small Molecule Metabolic Process Nitric Oxide Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Voluntary Musculoskeletal Movement Regulation Of Nitric-oxide Synthase Activity Oxidation-reduction Process	G1/S Transition Of Mitotic Cell Cycle Calcium Ion Transport Synaptic Transmission Nervous System Development Regulation Of Skeletal Muscle Adaptation Dephosphorylation Cytokine-mediated Signaling Pathway Insulin Secretion Cell Differentiation Cellular Response To Heat Protein Autophosphorylation Protein Oligomerization Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Relaxation Of Cardiac Muscle
Pathways		Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Interferon gamma signaling HSF1-dependent transactivation Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		Oxaloacetate Ion 2\'-Monophosphoadenosine 5\'-Diphosphoribose Biopterin N-Acetyl Serotonin
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CAMK2G YWHAQ	31 interactors: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CHAT CREM EGFR FLNA GRIA1 GRIA4 GRIN1 GRIN2B LRRC7 MYLK PEA15 PLCB3 PPM1F RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 SYN1 TH TIAM1
Entrez ID		6697	818
HPRD ID		01632	03672
Ensembl ID		ENSG00000116096	ENSG00000148660
Uniprot IDs		P35270	Q13280 Q13555 Q5SWX3
PDB IDs		1Z6Z 4HWK 4J7U	2UX0 2V7O
Enriched GO Terms of Interacting Partners?		Regulation Of Relaxation Of Cardiac Muscle Regulation Of Relaxation Of Muscle Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Insulin Secretion Protein Transport Establishment Of Protein Localization Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Cellular Response To Heat Peptide Hormone Secretion Peptide Secretion Protein Localization Hormone Secretion Midbrain Development Establishment Of Localization In Cell Hormone Transport Regulation Of Mitochondrion Organization Peptide Transport	Signaling Cell Communication Synaptic Transmission Cellular Response To Stimulus Cell-cell Signaling Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cellular Response To Growth Factor Stimulus Neuron-neuron Synaptic Transmission Signal Transduction Response To Growth Factor Response To Abiotic Stimulus Response To Organic Substance SMAD Protein Complex Assembly Cell Development Intracellular Signal Transduction Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Cellular Process Response To Organonitrogen Compound Cell Differentiation Cell Projection Organization Regulation Of Signaling Glutamate Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway System Development Multicellular Organismal Development Neuron Development Regulation Of Synaptic Transmission Platelet Degranulation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Secretion By Cell Anatomical Structure Morphogenesis Positive Regulation Of Cellular Component Movement Response To Stress Mesenchyme Development Organ Development Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Import Into Nucleus Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Neurotrophin Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Response To Amphetamine
Tagcloud ?			agouti cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?			agouti cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?