FURIN and SORCS1

Number of citations of the paper that reports this interaction (PMID 12482870)
9

Data Source:
HPRD (in vivo, in vitro)

		FURIN	SORCS1
Gene Name		furin (paired basic amino acid cleaving enzyme)	sortilin-related VPS10 domain containing receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Space Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Trans-Golgi Network Transport Vesicle Membrane Raft Extracellular Vesicular Exosome	Membrane Integral Component Of Membrane
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding	Protein Binding Neuropeptide Receptor Activity
	Biological Process	Signal Peptide Processing Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Pathogenesis Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Viral Process Protein Processing Peptide Hormone Processing Peptidyl-glutamic Acid Carboxylation Viral Life Cycle Virion Assembly Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Nerve Growth Factor Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity	Neuropeptide Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Elastic fibre formation HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Degradation of the extracellular matrix Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Assembly Of The HIV Virion HIV Life Cycle Uptake and actions of bacterial toxins NGF processing Removal of aminoterminal propeptides from gamma-carboxylated proteins Pre-NOTCH Expression and Processing Uptake and function of anthrax toxins Signaling by NODAL Signaling by PDGF Signalling by NGF TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Pre-NOTCH Processing in Golgi Loss of Function of SMAD2/3 in Cancer Post-translational protein modification Collagen degradation Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Activation of Matrix Metalloproteinases Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Synthesis and processing of ENV and VPU Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Gamma carboxylation, hypusine formation and arylsulfatase activation SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)	Endometriosis ( 23472165)
Protein-Protein Interactions		27 interactors: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 BACE1 COL23A1 DSG3 EDA FLNA FLNC ITM2C LECT1 LRP1 NAGPA NOTCH1 PACS1 PDGFA PMCH PRB4 SERPINB8 SORCS1 SORL1 TNFSF13 VWF ZP3 ZP4	2 interactors: FURIN SORT1
Entrez ID		5045	114815
HPRD ID		00653	12098
Ensembl ID		ENSG00000140564	ENSG00000108018
Uniprot IDs		P09958	A8K182 B3KVZ0 B3KWN9 E6Y3F9 E6Y3G0 Q8WY21
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Binding Of Sperm To Zona Pellucida Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Acrosome Reaction Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Multicellular Organismal Development Developmental Process Anatomical Structure Development Regulation Of Acrosome Reaction Platelet Degranulation Protein Targeting To Lysosome Regulation Of Cellular Localization Protein Localization To Lysosome Vesicle-mediated Transport Positive Regulation Of Transport Establishment Of Protein Localization Cellular Localization Hair Follicle Development Positive Regulation Of Humoral Immune Response Hair Cycle Process Positive Regulation Of Calcium Ion-dependent Exocytosis System Development Membrane Protein Ectodomain Proteolysis Secretion By Cell Protein Targeting To Golgi Hair Cycle Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Protein Targeting To Vacuole Regulation Of Defense Response To Virus By Virus Establishment Of Protein Localization To Vacuole Regulation Of Immune System Process Regulation Of Cell Migration Heart Trabecula Morphogenesis Protein Kinase C Signaling Positive Regulation Of Protein Transport Regulation Of Signal Transduction Exocytosis Regulation Of Cell Motility Secretion Protein Transport Regulation Of Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Membrane Protein Proteolysis Regulation Of Vesicle-mediated Transport Positive Regulation Of Intracellular Protein Transport Protein Localization To Golgi Apparatus Protein Localization Regulation Of Locomotion	Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Hydrolase Activity Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Lipoprotein Lipase Activity Plasma Membrane To Endosome Transport Cellular Response To Growth Factor Stimulus Response To Growth Factor Glucose Import Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Protein Processing Positive Regulation Of Membrane Protein Ectodomain Proteolysis Nerve Growth Factor Signaling Pathway Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Catalytic Activity Golgi To Endosome Transport Enzyme Linked Receptor Protein Signaling Pathway Signal Peptide Processing Negative Regulation Of Lipase Activity Virion Assembly Cellular Response To Nerve Growth Factor Stimulus Endosome To Lysosome Transport Peptide Biosynthetic Process Peptide Hormone Processing Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Lysosomal Transport Myotube Differentiation Collagen Catabolic Process Glucose Transport Negative Regulation Of Cellular Protein Catabolic Process Cellular Response To Organic Substance Hexose Transport Vacuolar Transport Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Neuropeptide Signaling Pathway Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity
Tagcloud ?		autophosphorylation c5 cleavage cleave cleaved convertases d4 endoproteolytic exclude greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive	adni associating atrophy classifier correct correction covariates discriminate enlargement enrollment esr1 etiology false happen initiative machines neurodegeneration neuroimaging personalized plans progresses snps sortilin span squares svm tf transferrin vps10
Tagcloud (Difference) ?		autophosphorylation c5 cleavage cleave cleaved convertases d4 endoproteolytic exclude greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive	adni associating atrophy classifier correct correction covariates discriminate enlargement enrollment esr1 etiology false happen initiative machines neurodegeneration neuroimaging personalized plans progresses snps sortilin span squares svm tf transferrin vps10
Tagcloud (Intersection) ?