SNTB1 and MAPK12

Number of citations of the paper that reports this interaction (PMID 10212242)
35

Data Source:
HPRD (two hybrid, in vitro)

		SNTB1	MAPK12
Gene Name		syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	mitogen-activated protein kinase 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Focal Adhesion Dystrophin-associated Glycoprotein Complex Sarcolemma Protein Complex Synapse	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Actin Binding Protein Binding Calmodulin Binding PDZ Domain Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Muscle Contraction	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Damage Induced Protein Phosphorylation Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Muscle Cell Differentiation Myoblast Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Muscle Cell Differentiation
Pathways			Signalling to ERKs Signalling by NGF Organelle biogenesis and maintenance CDO in myogenesis NGF signalling via TRKA from the plasma membrane VEGFA-VEGFR2 Pathway Mitochondrial biogenesis DSCAM interactions Activation of PPARGC1A (PGC-1alpha) by phosphorylation Myogenesis Signaling by VEGF NOD1/2 Signaling Pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways p38MAPK events Signalling to RAS Innate Immune System
Drugs
Diseases
GWAS		Myopia (pathological) ( 23406873)
Protein-Protein Interactions		11 interactors: ABCA1 ADRA1D BAI1 DGKZ DMD DTNA KCNJ12 MAPK12 SCN4A SCN5A UTRN	25 interactors: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBB2IP GRB2 GTF2I HTRA2 INADL MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PKN1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1
Entrez ID		6641	6300
HPRD ID		02490	03868
Ensembl ID		ENSG00000172164	ENSG00000188130
Uniprot IDs		Q13884	B7Z274 P53778
PDB IDs			1CM8
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Sodium Ion Transport Regulation Of Ion Transport Signaling Cell Communication Action Potential Striated Muscle Contraction Cell-cell Signaling Regulation Of Sodium Ion Transmembrane Transporter Activity Neuronal Action Potential Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Positive Regulation Of Sodium Ion Transport Regulation Of Membrane Potential Muscle Organ Development Cardiac Muscle Contraction Positive Regulation Of Cell-matrix Adhesion Transmission Of Nerve Impulse Blood Circulation Heart Contraction Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cellular Process Regulation Of Striated Muscle Contraction Establishment Of Glial Blood-brain Barrier Peripheral Nervous System Development Membrane Depolarization Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion G-protein Coupled Receptor Signaling Pathway Muscle Structure Development Negative Regulation Of Peptidyl-cysteine S-nitrosylation Membrane Depolarization During SA Node Cell Action Potential Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Interleukin-1 Beta Secretion Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Synaptic Transmission Ion Transmembrane Transport Regulation Of Muscle Contraction SA Node Cell Action Potential Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Establishment Of Blood-nerve Barrier AV Node Cell To Bundle Of His Cell Communication Cellular Response To Stimulus	Receptor Localization To Synapse Regulation Of Phosphorus Metabolic Process Protein Localization To Synapse Regulation Of Catalytic Activity Regulation Of MAP Kinase Activity Regulation Of Cellular Protein Metabolic Process Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Signaling Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Cell Communication Regulation Of Metabolic Process Regulation Of MAPK Cascade Muscle System Process Receptor Clustering Activation Of Protein Kinase Activity Activation Of MAPK Activity Nucleotide Phosphorylation Response To Stimulus Regulation Of Cellular Process Phosphorylation Intracellular Signal Transduction Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of MAP Kinase Activity Muscle Contraction Cellular Response To Sorbitol MAPK Cascade Positive Regulation Of Protein Polymerization Positive Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Axonogenesis Positive Regulation Of Transferase Activity Regulation Of Signaling Axon Development Cell Morphogenesis Involved In Neuron Differentiation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Apoptotic Process
Tagcloud ?			6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapped microarray nab2 persistently perturbed plcg1 ppp4c radiation runx1 scarcity sema4d stathmin1 surgically undertook
Tagcloud (Difference) ?			6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapped microarray nab2 persistently perturbed plcg1 ppp4c radiation runx1 scarcity sema4d stathmin1 surgically undertook
Tagcloud (Intersection) ?