MAPK12 and SH3BP5

Number of citations of the paper that reports this interaction (PMID 15158451)
7

Data Source:
HPRD (in vitro)

		MAPK12	SH3BP5
Gene Name		mitogen-activated protein kinase 12	SH3-domain binding protein 5 (BTK-associated)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol	Cytoplasm Mitochondrion
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Protein Kinase Inhibitor Activity Protein Binding SH3 Domain Binding
	Biological Process	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Damage Induced Protein Phosphorylation Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Muscle Cell Differentiation Myoblast Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Muscle Cell Differentiation	Negative Regulation Of Protein Kinase Activity Signal Transduction Intracellular Signal Transduction
Pathways		Signalling to ERKs Signalling by NGF Organelle biogenesis and maintenance CDO in myogenesis NGF signalling via TRKA from the plasma membrane VEGFA-VEGFR2 Pathway Mitochondrial biogenesis DSCAM interactions Activation of PPARGC1A (PGC-1alpha) by phosphorylation Myogenesis Signaling by VEGF NOD1/2 Signaling Pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways p38MAPK events Signalling to RAS Innate Immune System
Drugs
Diseases
GWAS			Alcohol and nictotine co-dependence ( 22488850) Alcohol dependence ( 21956439)
Protein-Protein Interactions		25 interactors: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBB2IP GRB2 GTF2I HTRA2 INADL MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PKN1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1	14 interactors: APP BTK CDC5L DISC1 DST EXOC1 MAPK10 MAPK12 MAPK8 MAPK9 SOS1 SPTBN1 SYNE1 TNKS
Entrez ID		6300	9467
HPRD ID		03868	12030
Ensembl ID		ENSG00000188130	ENSG00000131370
Uniprot IDs		B7Z274 P53778	O60239
PDB IDs		1CM8	4H3B
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Regulation Of Phosphorus Metabolic Process Protein Localization To Synapse Regulation Of Catalytic Activity Regulation Of MAP Kinase Activity Regulation Of Cellular Protein Metabolic Process Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Signaling Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Cell Communication Regulation Of Metabolic Process Regulation Of MAPK Cascade Muscle System Process Receptor Clustering Activation Of Protein Kinase Activity Activation Of MAPK Activity Nucleotide Phosphorylation Response To Stimulus Regulation Of Cellular Process Phosphorylation Intracellular Signal Transduction Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of MAP Kinase Activity Muscle Contraction Cellular Response To Sorbitol MAPK Cascade Positive Regulation Of Protein Polymerization Positive Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Axonogenesis Positive Regulation Of Transferase Activity Regulation Of Signaling Axon Development Cell Morphogenesis Involved In Neuron Differentiation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Apoptotic Process	JUN Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Surface Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Phosphorylation Fc Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Cell Communication Phosphorylation Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction By Phosphorylation JNK Cascade Cellular Localization Positive Regulation Of Proteolysis Regulation Of Circadian Rhythm Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Light Stimulus Apoptotic Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Immune Response Defense Response Phosphate-containing Compound Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Immune Response
Tagcloud ?		6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapped microarray nab2 persistently perturbed plcg1 ppp4c radiation runx1 scarcity sema4d stathmin1 surgically undertook	activator apollon bioactive bruce context deaths effector familial heterotrimeric hthnr humanin inhibits jaks janus linked london member neuronal occurs precursor sole stat3 transducer unusual upregulated v642i variety via
Tagcloud (Difference) ?		6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapped microarray nab2 persistently perturbed plcg1 ppp4c radiation runx1 scarcity sema4d stathmin1 surgically undertook	activator apollon bioactive bruce context deaths effector familial heterotrimeric hthnr humanin inhibits jaks janus linked london member neuronal occurs precursor sole stat3 transducer unusual upregulated v642i variety via
Tagcloud (Intersection) ?