SLC6A4 and CALR

Number of citations of the paper that reports this interaction (PMID 10364189)
13

Data Source:
HPRD (in vivo)

		SLC6A4	CALR
Gene Name		solute carrier family 6 (neurotransmitter transporter), member 4	calreticulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Endomembrane System Neuron Projection Membrane Raft	Acrosomal Vesicle Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Intracellular Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Sarcoplasmic Reticulum Lumen MHC Class I Peptide Loading Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen
	Molecular Function	Serotonin:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Serotonin Transmembrane Transporter Activity Myosin Binding Syntaxin-1 Binding Rab GTPase Binding Cocaine Binding Protein Homodimerization Activity Nitric-oxide Synthase Binding Actin Filament Binding	Complement Component C1q Binding Glycoprotein Binding DNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Binding Involved In Protein Folding Poly(A) RNA Binding Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Response To Hypoxia Serotonin Transport Response To Nutrient Memory Circadian Rhythm Response To Toxic Substance Positive Regulation Of Gene Expression Monoamine Transport Thalamus Development Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Social Behavior Vasoconstriction Response To Drug Sperm Ejaculation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Brain Morphogenesis Protein Oligomerization Protein Homooligomerization Serotonin Uptake Transmembrane Transport Cellular Response To Retinoic Acid Cellular Response To CGMP	Negative Regulation Of Transcription From RNA Polymerase II Promoter Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein N-linked Glycosylation Via Asparagine Protein Maturation By Protein Folding Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Regulation Of Meiosis Response To Drug Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Cardiac Muscle Cell Differentiation Chaperone-mediated Protein Folding Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Dendritic Cell Chemotaxis
Pathways			Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Scavenging by Class F Receptors Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Scavenging by Class A Receptors Assembly of Viral Components at the Budding Site ATF6-alpha activates chaperones Unfolded Protein Response (UPR) Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) ATF6-alpha activates chaperone genes Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Antigen processing-Cross presentation ER-Phagosome pathway Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs		Fluvoxamine Phentermine Tramadol Citalopram Venlafaxine Atomoxetine Amitriptyline Protriptyline Methylphenidate Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Clomipramine Ephedra MMDA 3,4-Methylenedioxymethamphetamine 4-Methoxyamphetamine Methamphetamine Zimelidine Amineptine Milnacipran Mianserin Tapentadol Desvenlafaxine Dexmethylphenidate Levomilnacipran
Diseases
GWAS			Red blood cell traits ( 23222517)
Protein-Protein Interactions		4 interactors: CALR CANX STX1A YBX1	39 interactors: APOB APP AR B2M CD1D F5 F8 FBN1 FGB HLA-A HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 PDIA2 PDIA3 PLAT PLP1 PRF1 SCARF1 SLC2A1 SLC6A4 SMARCB1 SUMO4 TAPBP TF THBS1 TSHR UPF2 VWF
Entrez ID		6532	811
HPRD ID		01640	00169
Ensembl ID		ENSG00000108576	ENSG00000179218
Uniprot IDs		B2R7Y7 P31645	P27797
PDB IDs			2CLR 3DOW 3POS 3POW
Enriched GO Terms of Interacting Partners?		Chaperone-mediated Protein Folding Protein N-linked Glycosylation Via Asparagine Synaptic Vesicle Transport Protein N-linked Glycosylation Peptide Antigen Assembly With MHC Class I Protein Complex Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Establishment Of Vesicle Localization Post-translational Protein Modification Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Sequestering Of Calcium Ion Regulation Of Cell Division CRD-mediated MRNA Stabilization Protein Transport Protein Folding Vesicle-mediated Transport Antigen Processing And Presentation Establishment Of Protein Localization Aging Positive Regulation Of Dendritic Cell Chemotaxis Establishment Of Organelle Localization Protein Glycosylation Macromolecule Glycosylation Glycosylation Receptor-mediated Endocytosis Glucocorticoid Receptor Signaling Pathway Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Regulation Of Vesicle-mediated Transport Glycoprotein Biosynthetic Process Sequestering Of Metal Ion Organelle Localization Synaptic Vesicle Fusion To Presynaptic Membrane Protein Maturation By Protein Folding Protein Localization Glycoprotein Metabolic Process Posttranscriptional Regulation Of Gene Expression Establishment Of Localization In Cell Response To Gravity Positive Regulation Of Neurotransmitter Secretion Secretion By Cell Cellular Response To Lithium Ion Negative Regulation Of Striated Muscle Cell Differentiation Synaptic Transmission Cellular Localization Glutamate Secretion Secretion Cortical Actin Cytoskeleton Organization Endocytosis MRNA Stabilization	Response To Stimulus Response To Stress Platelet Degranulation Blood Coagulation Hemostasis Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Body Fluid Levels Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Wound Healing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cell Activation Response To Wounding Platelet Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Exocytosis Response To External Stimulus Cellular Response To Stimulus Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Defense Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I System Development Secretion By Cell Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Cell Communication Immune Response Behavior Positive Regulation Of Leukocyte Mediated Cytotoxicity Transport Secretion Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Protection From Natural Killer Cell Mediated Cytotoxicity Signaling Multicellular Organismal Development Signal Transduction Negative Regulation Of Signaling Cell Adhesion Response To Hormone Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Anatomical Structure Development Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Organic Substance
Tagcloud ?		adjective analyze anxiety authors bp check genotype genotypes homogeneous htt httlpr inventory list mao measuring menopausal mood nevertheless poland polymorphism possibility postmenopausal promoter prove region respondents slight trait vntr	administrating aspirin avws busulfan calreticulin erythrocytosis expectancy extreme failures fibrotic hematocrit hematol hydroxyurea leukocytosis microcirculatory periodicals phlebotomy prefibrotic pruritus pv splenomegaly stratification survivals thrombocytosis thrombohemorrhagic thrombosis von wiley willebrand
Tagcloud (Difference) ?		adjective analyze anxiety authors bp check genotype genotypes homogeneous htt httlpr inventory list mao measuring menopausal mood nevertheless poland polymorphism possibility postmenopausal promoter prove region respondents slight trait vntr	administrating aspirin avws busulfan calreticulin erythrocytosis expectancy extreme failures fibrotic hematocrit hematol hydroxyurea leukocytosis microcirculatory periodicals phlebotomy prefibrotic pruritus pv splenomegaly stratification survivals thrombocytosis thrombohemorrhagic thrombosis von wiley willebrand
Tagcloud (Intersection) ?