SLC6A4 and YBX1

Number of citations of the paper that reports this interaction (PMID 15229244)
12

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SLC6A4	YBX1
Gene Name		solute carrier family 6 (neurotransmitter transporter), member 4	Y box binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Endomembrane System Neuron Projection Membrane Raft	Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Cytoplasmic Stress Granule Ribonucleoprotein Complex Nuclear Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex
	Molecular Function	Serotonin:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Serotonin Transmembrane Transporter Activity Myosin Binding Syntaxin-1 Binding Rab GTPase Binding Cocaine Binding Protein Homodimerization Activity Nitric-oxide Synthase Binding Actin Filament Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Response To Hypoxia Serotonin Transport Response To Nutrient Memory Circadian Rhythm Response To Toxic Substance Positive Regulation Of Gene Expression Monoamine Transport Thalamus Development Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Social Behavior Vasoconstriction Response To Drug Sperm Ejaculation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Brain Morphogenesis Protein Oligomerization Protein Homooligomerization Serotonin Uptake Transmembrane Transport Cellular Response To Retinoic Acid Cellular Response To CGMP	Negative Regulation Of Transcription From RNA Polymerase II Promoter MRNA Splicing, Via Spliceosome In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Splicing Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs		Fluvoxamine Phentermine Tramadol Citalopram Venlafaxine Atomoxetine Amitriptyline Protriptyline Methylphenidate Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Clomipramine Ephedra MMDA 3,4-Methylenedioxymethamphetamine 4-Methoxyamphetamine Methamphetamine Zimelidine Amineptine Milnacipran Mianserin Tapentadol Desvenlafaxine Dexmethylphenidate Levomilnacipran
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CALR CANX STX1A YBX1	41 interactors: ACTA2 AKT1 ANKRD2 APBB1 CALM1 CSNK2A1 CTCF FBXO33 FMR1 FUS GSK3B HABP4 HIST1H1C HLA-C HNRNPD HNRNPK IL7R IREB2 IRF1 JAM2 LCP2 LSM3 MAPK1 NFYB PCBP2 PCNA PRPF40A PURA RBBP6 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 UBC VEGFA
Entrez ID		6532	4904
HPRD ID		01640	01095
Ensembl ID		ENSG00000108576	ENSG00000065978
Uniprot IDs		B2R7Y7 P31645	P67809
PDB IDs			1H95
Enriched GO Terms of Interacting Partners?		Chaperone-mediated Protein Folding Protein N-linked Glycosylation Via Asparagine Synaptic Vesicle Transport Protein N-linked Glycosylation Peptide Antigen Assembly With MHC Class I Protein Complex Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Establishment Of Vesicle Localization Post-translational Protein Modification Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Sequestering Of Calcium Ion Regulation Of Cell Division CRD-mediated MRNA Stabilization Protein Transport Protein Folding Vesicle-mediated Transport Antigen Processing And Presentation Establishment Of Protein Localization Aging Positive Regulation Of Dendritic Cell Chemotaxis Establishment Of Organelle Localization Protein Glycosylation Macromolecule Glycosylation Glycosylation Receptor-mediated Endocytosis Glucocorticoid Receptor Signaling Pathway Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Regulation Of Vesicle-mediated Transport Glycoprotein Biosynthetic Process Sequestering Of Metal Ion Organelle Localization Synaptic Vesicle Fusion To Presynaptic Membrane Protein Maturation By Protein Folding Protein Localization Glycoprotein Metabolic Process Posttranscriptional Regulation Of Gene Expression Establishment Of Localization In Cell Response To Gravity Positive Regulation Of Neurotransmitter Secretion Secretion By Cell Cellular Response To Lithium Ion Negative Regulation Of Striated Muscle Cell Differentiation Synaptic Transmission Cellular Localization Glutamate Secretion Secretion Cortical Actin Cytoskeleton Organization Endocytosis MRNA Stabilization	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Immune Response Immune Response Regulation Of Immune System Process Negative Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Immune System Process Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Apoptotic Process Neurotrophin Signaling Pathway Innate Immune Response RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Growth Programmed Cell Death Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Cell Activation Regulation Of Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Regulation Of Cell Differentiation System Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Translation Negative Regulation Of Biosynthetic Process Gene Expression Blood Coagulation Hemostasis Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Wound Healing Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Growth Regulation Of RNA Metabolic Process Regulation Of Growth Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		adjective analyze anxiety authors bp check genotype genotypes homogeneous htt httlpr inventory list mao measuring menopausal mood nevertheless poland polymorphism possibility postmenopausal promoter prove region respondents slight trait vntr	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 yy1 zfhx3 zfp36 zmat3
Tagcloud (Difference) ?		adjective analyze anxiety authors bp check genotype genotypes homogeneous htt httlpr inventory list mao measuring menopausal mood nevertheless poland polymorphism possibility postmenopausal promoter prove region respondents slight trait vntr	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 yy1 zfhx3 zfp36 zmat3
Tagcloud (Intersection) ?