PINK1 and SNCAIP

Number of citations of the paper that reports this interaction (PMID 15894486)
10

Data Source:
BioGRID (two hybrid)

		PINK1	SNCAIP
Gene Name		PTEN induced putative kinase 1	synuclein, alpha interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Membrane Axon Integral Component Of Mitochondrial Outer Membrane TORC2 Complex Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection	Cytoplasm Synaptic Vesicle Presynaptic Membrane Neuronal Cell Body
	Molecular Function	Magnesium Ion Binding Protease Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Calcium-dependent Protein Kinase Activity Kinase Activity Peptidase Activator Activity Ubiquitin Protein Ligase Binding Protein Kinase B Binding C3HC4-type RING Finger Domain Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Mitochondrion Degradation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Response To Stress Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Peptidase Activity Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Respiratory Electron Transport Chain Regulation Of Protein Ubiquitination Activation Of Protein Kinase B Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Dopamine Secretion Cellular Response To Oxidative Stress Positive Regulation Of Protein Dephosphorylation Intracellular Signal Transduction Peptidyl-serine Autophosphorylation TORC2 Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Negative Regulation Of JNK Cascade Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Cellular Response To Hypoxia Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Synaptic Vesicle Transport Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Mitochondrion Degradation Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Dopamine Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BAG2 CRLS1 EED FBXO7 MAP3K7 MARK2 PARK7 PGAM5 SNCA SNCAIP TRAF6 UBC UBE2M	19 interactors: AES AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PARK2 PINK1 PPHLN1 PPP1CA PTN RNF19A SEPT4 SH2D3C SIAH1 SIAH2 SNCA UBB
Entrez ID		65018	9627
HPRD ID		10514	04804
Ensembl ID		ENSG00000158828	ENSG00000064692
Uniprot IDs		Q9BXM7	Q9NVG1 Q9Y6H5
PDB IDs			2KES
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Cellular Response To Growth Factor Stimulus Cell Death Death Toll-like Receptor 4 Signaling Pathway Response To Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Oxidative Phosphorylation JNK Cascade Dopamine Transport Cellular Metabolic Process Regulation Of Cellular Respiration Neurotransmitter Uptake Synaptic Transmission, Dopaminergic Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway	Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Proteolysis Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Protein Ubiquitination Regulation Of Proteolysis Regulation Of Dopamine Secretion Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Dopamine Uptake Involved In Synaptic Transmission Modification-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Synaptic Vesicle Transport Regulation Of Signaling Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitochondrion Organization Positive Regulation Of Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Glycogen Metabolic Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process
Tagcloud ?		aberration afford atpase controlling dramatic ectopic entry fission irreversible maturation mediates nervous neurodegeneration neurodegenerative neurogenesis neuronal oxidant oxidative physiologically precise premature programmed pten rationale reproted restores suppressing thapsigargin ubiquitously	adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 ranbp2 respective rps6kl1 sequenced spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Difference) ?		aberration afford atpase controlling dramatic ectopic entry fission irreversible maturation mediates nervous neurodegeneration neurodegenerative neurogenesis neuronal oxidant oxidative physiologically precise premature programmed pten rationale reproted restores suppressing thapsigargin ubiquitously	adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 ranbp2 respective rps6kl1 sequenced spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Intersection) ?