PINK1 and BAG2

Number of citations of the paper that reports this interaction (PMID 24513209)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PINK1	BAG2
Gene Name		PTEN induced putative kinase 1	BCL2-associated athanogene 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Membrane Axon Integral Component Of Mitochondrial Outer Membrane TORC2 Complex Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection
	Molecular Function	Magnesium Ion Binding Protease Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Calcium-dependent Protein Kinase Activity Kinase Activity Peptidase Activator Activity Ubiquitin Protein Ligase Binding Protein Kinase B Binding C3HC4-type RING Finger Domain Binding	Protein Binding Identical Protein Binding Chaperone Binding
	Biological Process	Mitochondrion Degradation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Response To Stress Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Peptidase Activity Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Respiratory Electron Transport Chain Regulation Of Protein Ubiquitination Activation Of Protein Kinase B Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Dopamine Secretion Cellular Response To Oxidative Stress Positive Regulation Of Protein Dephosphorylation Intracellular Signal Transduction Peptidyl-serine Autophosphorylation TORC2 Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Negative Regulation Of JNK Cascade Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Cellular Response To Hypoxia Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Synaptic Vesicle Transport Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Mitochondrion Degradation Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Protein Folding Protein Metabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BAG2 CRLS1 EED FBXO7 MAP3K7 MARK2 PARK7 PGAM5 SNCA SNCAIP TRAF6 UBC UBE2M	12 interactors: CCAR2 DNAJC6 HSPA1A HSPA4 HSPA8 MAPKAPK2 NOTCH3 PINK1 PPIH SLU7 WDR77 WDR83
Entrez ID		65018	9532
HPRD ID		10514	04859
Ensembl ID		ENSG00000158828
Uniprot IDs		Q9BXM7	B4DXE2 O95816
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Cellular Response To Growth Factor Stimulus Cell Death Death Toll-like Receptor 4 Signaling Pathway Response To Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Oxidative Phosphorylation JNK Cascade Dopamine Transport Cellular Metabolic Process Regulation Of Cellular Respiration Neurotransmitter Uptake Synaptic Transmission, Dopaminergic Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway	Cellular Response To Heat Regulation Of Cellular Response To Heat Response To Heat MRNA Metabolic Process RNA Splicing Response To Temperature Stimulus MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Clathrin Coat Disassembly Gene Expression Response To Abiotic Stimulus RNA Metabolic Process Response To Unfolded Protein Regulation Of Protein Stability Cellular Response To Stress Protein Refolding Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Apoptotic Signaling Pathway Protein Folding Nucleobase-containing Compound Metabolic Process Response To Stress Positive Regulation Of DNA Damage Checkpoint Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Fibril Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Post-Golgi Vesicle-mediated Transport Mitochondrion Organization Protein Stabilization Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Cellular Heat Acclimation Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Fibril Organization Nitrogen Compound Metabolic Process Peptidyl-serine Phosphorylation Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Protein Import Into Mitochondrial Outer Membrane Positive Regulation Of Cellular Respiration Cellular Protein Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death MRNA 3'-splice Site Recognition Regulation Of Cellular Response To Hypoxia
Tagcloud ?		aberration afford atpase controlling dramatic ectopic entry fission irreversible maturation mediates nervous neurodegeneration neurodegenerative neurogenesis neuronal oxidant oxidative physiologically precise premature programmed pten rationale reproted restores suppressing thapsigargin ubiquitously	abolished ameliorates athanogene balance collapse cytochrome dimer disassociation dj elucidated homodimer link modulating monomer monomerization mpp neurodegeneration neuroprotective overexpressed overexpressing parkinson partners pd phenylpyridinium prevents property pulldown strengthening
Tagcloud (Difference) ?		aberration afford atpase controlling dramatic ectopic entry fission irreversible maturation mediates nervous neurodegenerative neurogenesis neuronal oxidant oxidative physiologically precise premature programmed pten rationale reproted restores suppressing thapsigargin ubiquitously	abolished ameliorates athanogene balance collapse cytochrome dimer disassociation dj elucidated homodimer link modulating monomer monomerization mpp neuroprotective overexpressed overexpressing parkinson partners pd phenylpyridinium prevents property pulldown strengthening
Tagcloud (Intersection) ?		neurodegeneration