SHMT1 and MAPK9

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SHMT1	MAPK9
Gene Name		serine hydroxymethyltransferase 1 (soluble)	mitogen-activated protein kinase 9
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Nucleoplasm Mitochondrion Cytosol
	Molecular Function	Glycine Hydroxymethyltransferase Activity L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity	JUN Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	L-serine Catabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Purine Nucleobase Biosynthetic Process Glycine Biosynthetic Process From Serine Cellular Nitrogen Compound Metabolic Process Tetrahydrofolate Interconversion Small Molecule Metabolic Process Carnitine Biosynthetic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization	Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Protein Targeting To Mitochondrion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Stress JNK Cascade JUN Phosphorylation Central Nervous System Development Response To Mechanical Stimulus Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Response To Amine Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Protein Ubiquitination Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Chemokine Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To UV TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Regulation Of Circadian Rhythm Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of JNK Cascade Response To Cadmium Ion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Metabolism of amino acids and derivatives Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Carnitine synthesis Metabolism of folate and pterines Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism	Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases
Drugs		Pyridoxal Phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-Formyl-Tetrahydrofolate 5-Hydroxymethylene-6-Hydrofolic Acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CSNK2B DEDD DLEU1 MAPK9 PIM1 PRSS23 SULT1A3	70 interactors: ACP5 ARRB1 ARRB2 ATF2 ATF7 BAZ1B BCL2L11 C1orf94 CASP3 CCDC33 CDC25B CDC25C CEP44 CLU CTBP1 CTNNB1 CYHR1 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 ELK1 ELK3 GRB2 H3F3A HDAC9 HSF1 IRS1 JDP2 JUN JUNB JUND KIAA1377 L3MBTL3 LMAN2 LNX1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MEOX1 NCF1 NFATC3 NFATC4 PRKD1 RB1 RPS6KB1 SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25
Entrez ID		6470	5601
HPRD ID		01643	04206
Ensembl ID		ENSG00000176974	ENSG00000050748
Uniprot IDs		B4DPM9 P34896	P45984
PDB IDs		1BJ4	3E7O 3NPC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter JUN Phosphorylation Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Positive Regulation Of Prostaglandin Biosynthetic Process Cell Death Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Endothelial Tube Morphogenesis Protein Phosphorylation Apoptotic Signaling Pathway Protein Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Apoptotic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Cell Death Positive Regulation Of Icosanoid Secretion Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Metabolic Process Sulfation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Fatty Acid Transport Flavonoid Metabolic Process Decidualization Positive Regulation Of Macrophage Derived Foam Cell Differentiation	Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process MAPK Cascade Intracellular Signal Transduction Regulation Of Kinase Activity Apoptotic Process Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Negative Regulation Of Cellular Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Cellular Biosynthetic Process Developmental Process Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Neuron Death Positive Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Defense Response Cellular Metabolic Process Cellular Response To Stress Regulation Of Signaling Regulation Of Gene Expression Anatomical Structure Development Cell Differentiation Positive Regulation Of Phosphorylation Signal Transduction Toll-like Receptor 4 Signaling Pathway Immune System Process Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Regulation Of JUN Kinase Activity Signaling
Tagcloud ?		aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights slc19a1 snps tyms	abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk8 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles
Tagcloud (Difference) ?		aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights slc19a1 snps tyms	abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk8 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles
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