SHMT1 and PRSS23

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHMT1	PRSS23
Gene Name		serine hydroxymethyltransferase 1 (soluble)	protease, serine, 23
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Nucleus Extracellular Vesicular Exosome
	Molecular Function	Glycine Hydroxymethyltransferase Activity L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity	Serine-type Endopeptidase Activity
	Biological Process	L-serine Catabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Purine Nucleobase Biosynthetic Process Glycine Biosynthetic Process From Serine Cellular Nitrogen Compound Metabolic Process Tetrahydrofolate Interconversion Small Molecule Metabolic Process Carnitine Biosynthetic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization	Proteolysis
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Metabolism of amino acids and derivatives Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Carnitine synthesis Metabolism of folate and pterines Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Pyridoxal Phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-Formyl-Tetrahydrofolate 5-Hydroxymethylene-6-Hydrofolic Acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CSNK2B DEDD DLEU1 MAPK9 PIM1 PRSS23 SULT1A3	25 interactors: ACTG1 APP B2M CHP1 EFNA3 FXR1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDDC1 PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4
Entrez ID		6470	11098
HPRD ID		01643	07149
Ensembl ID		ENSG00000176974	ENSG00000150687
Uniprot IDs		B4DPM9 P34896	B4E2J3 O95084
PDB IDs		1BJ4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter JUN Phosphorylation Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Positive Regulation Of Prostaglandin Biosynthetic Process Cell Death Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Endothelial Tube Morphogenesis Protein Phosphorylation Apoptotic Signaling Pathway Protein Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Apoptotic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Cell Death Positive Regulation Of Icosanoid Secretion Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Metabolic Process Sulfation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Fatty Acid Transport Flavonoid Metabolic Process Decidualization Positive Regulation Of Macrophage Derived Foam Cell Differentiation	Platelet Activation Blood Coagulation Hemostasis Cell Differentiation Cellular Component Assembly Regulation Of Body Fluid Levels Organelle Organization Wound Healing Multicellular Organismal Development Generation Of Neurons Cell Activation Dendrite Development System Development Response To Stress Response To Wounding Neurogenesis Mating Behavior Nervous System Development Regulation Of Protein Localization Response To Stimulus Neuron Projection Development Cell Development Developmental Process Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Uncoating Of Virus Mating Anatomical Structure Development Neuron Development Retina Homeostasis Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Protein Targeting To Mitochondrion Protein Complex Assembly Regulation Of Cellular Localization Immune System Process Platelet Degranulation Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Synaptic Growth At Neuromuscular Junction Active Induction Of Host Immune Response By Virus Mitotic Sister Chromatid Segregation Protein Localization To Mitochondrion Protein Folding Cognition Neuron Projection Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Mitotic Nuclear Division Sister Chromatid Segregation Regulation Of Establishment Of Protein Localization
Tagcloud ?		aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights slc19a1 snps tyms
Tagcloud (Difference) ?		aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights slc19a1 snps tyms
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