CCL23 and CCR1

Number of citations of the paper that reports this interaction (PMID 9558365)
12

Data Source:
HPRD (in vivo)

		CCL23	CCR1
Gene Name		chemokine (C-C motif) ligand 23	chemokine (C-C motif) receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Proliferation Negative Regulation Of C-C Chemokine Binding	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Metabolic Process Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140)
Protein-Protein Interactions		1 interactors: CCR1	20 interactors: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CREB3 GNA14 JAK1 PLP2 STAT1 STAT3 TPST1 TPST2
Entrez ID		6368	1230
HPRD ID		03930	03101
Ensembl ID		ENSG00000167236	ENSG00000163823
Uniprot IDs		P55773	P32246 Q5U003
PDB IDs		1G91	1Y5D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Monocyte Chemotaxis Dendritic Cell Chemotaxis Regulation Of Monocyte Chemotaxis Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Dendritic Cell Migration Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Regulation Of Osteoclast Differentiation Regulation Of Bone Mineralization Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Ossification Positive Regulation Of Leukocyte Migration Positive Regulation Of Calcium Ion Transport Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Myeloid Leukocyte Differentiation Regulation Of Leukocyte Migration Positive Regulation Of Behavior Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Chemotaxis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Chemotaxis Regulation Of Myeloid Cell Differentiation Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Regulation Of ERK1 And ERK2 Cascade Regulation Of Calcium Ion Transport Regulation Of Ossification Positive Regulation Of Ion Transport Leukocyte Migration Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Calcium Ion Transport Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Exocytosis Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cellular Metal Ion Homeostasis Inflammatory Response Cellular Cation Homeostasis Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Metal Ion Homeostasis Secretion By Cell	Cell Chemotaxis Chemotaxis Inflammatory Response Locomotion Cell Migration Cell Motility Immune Response Defense Response Response To External Stimulus Movement Of Cell Or Subcellular Component Monocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Cellular Calcium Ion Homeostasis Immune System Process Calcium Ion Homeostasis Positive Regulation Of Leukocyte Migration Response To Stress Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Chemical Homeostasis Cellular Metal Ion Homeostasis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Chemotaxis Regulation Of Behavior Positive Regulation Of Cellular Component Movement Ion Homeostasis Positive Regulation Of Locomotion Cellular Response To Stimulus Positive Regulation Of Calcium Ion Transport Regulation Of Cell Migration Cell-cell Signaling Regulation Of Cell Motility Leukocyte Chemotaxis Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Eosinophil Chemotaxis Regulation Of Locomotion Homeostatic Process Regulation Of Cellular Component Movement Eosinophil Migration Cellular Homeostasis
Tagcloud ?		17f blinded chemokines clues cut cxcl10 cxcr3 diagnosing discovery facilitate febrile globally immunoglobulin ip kawasaki kd mpif notable pg proteomic rationale receiver returned scd40l selectin suggestive unbiased validation vasculitis	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		17f blinded clues cut cxcl10 cxcr3 diagnosing discovery facilitate febrile globally immunoglobulin ip kawasaki kd mpif notable pg proteomic rationale receiver returned scd40l selectin suggestive unbiased validation vasculitis	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?		chemokines