CCR1 and TPST2

Number of citations of the paper that reports this interaction (PMID 17558413)
13

Data Source:
HPRD (in vitro)

		CCR1	TPST2
Gene Name		chemokine (C-C motif) receptor 1	tyrosylprotein sulfotransferase 2
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Protein-tyrosine Sulfotransferase Activity
	Biological Process	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Metabolic Process Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis	Peptidyl-tyrosine Sulfation Fusion Of Sperm To Egg Plasma Membrane Prevention Of Polyspermy
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140)
Protein-Protein Interactions		20 interactors: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CREB3 GNA14 JAK1 PLP2 STAT1 STAT3 TPST1 TPST2	5 interactors: CCR1 CCR8 CMKLR1 GPR1 SELPLG
Entrez ID		1230	8459
HPRD ID		03101	07217
Ensembl ID		ENSG00000163823	ENSG00000128294
Uniprot IDs		P32246 Q5U003	O60704
PDB IDs		1Y5D	3AP1 3AP2 3AP3
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Chemotaxis Inflammatory Response Locomotion Cell Migration Cell Motility Immune Response Defense Response Response To External Stimulus Movement Of Cell Or Subcellular Component Monocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Cellular Calcium Ion Homeostasis Immune System Process Calcium Ion Homeostasis Positive Regulation Of Leukocyte Migration Response To Stress Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Chemical Homeostasis Cellular Metal Ion Homeostasis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Chemotaxis Regulation Of Behavior Positive Regulation Of Cellular Component Movement Ion Homeostasis Positive Regulation Of Locomotion Cellular Response To Stimulus Positive Regulation Of Calcium Ion Transport Regulation Of Cell Migration Cell-cell Signaling Regulation Of Cell Motility Leukocyte Chemotaxis Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Eosinophil Chemotaxis Regulation Of Locomotion Homeostatic Process Regulation Of Cellular Component Movement Eosinophil Migration Cellular Homeostasis	Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine G-protein Coupled Receptor Signaling Pathway Locomotion Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemotaxis Cellular Response To Organic Substance Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Immune System Process Regulation Of Chemotaxis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Leukocyte Adhesive Activation Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Response To Organic Substance Regulation Of Behavior Leukocyte Migration Cell Adhesion Cell Surface Receptor Signaling Pathway Immune Response Cellular Calcium Ion Homeostasis Positive Regulation Of Macrophage Chemotaxis Calcium Ion Homeostasis Cellular Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Monocyte Chemotaxis Leukocyte Tethering Or Rolling Cellular Metal Ion Homeostasis Regulation Of Macrophage Chemotaxis Regulation Of Monocyte Chemotaxis Dendritic Cell Chemotaxis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To External Stimulus Negative Regulation Of Interleukin-12 Production Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Cellular Chemical Homeostasis Response To Stimulus Dendritic Cell Migration Ion Homeostasis
Tagcloud ?		7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	ameliorates backcross catalyzes ch chr chrs congenic d2mit255 d2mit304 d2mit62 dw dwarfism genetical grt hypoplasia hyporesponsiveness hypothyroidism indispensable linkage organogenesis progenies qtl qtls sulfation sulfotransferase svjcl ter thyroid tyrosylprotein
Tagcloud (Difference) ?		7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	ameliorates backcross catalyzes ch chr chrs congenic d2mit255 d2mit304 d2mit62 dw dwarfism genetical grt hypoplasia hyporesponsiveness hypothyroidism indispensable linkage organogenesis progenies qtl qtls sulfation sulfotransferase svjcl ter thyroid tyrosylprotein
Tagcloud (Intersection) ?