CCL14 and CCR1

Number of citations of the paper that reports this interaction (PMID 11085751)
15

Data Source:
HPRD (in vivo, in vitro)

		CCL14	CCR1
Gene Name		chemokine (C-C motif) ligand 14	chemokine (C-C motif) receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Chemokine Activity	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Cellular Calcium Ion Homeostasis Immune Response Positive Regulation Of Cell Proliferation Cell Chemotaxis	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Metabolic Process Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140)
Protein-Protein Interactions		7 interactors: ACKR2 AKT2 CCR1 CCR3 CCR5 DDX39A PIK3R1	20 interactors: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CREB3 GNA14 JAK1 PLP2 STAT1 STAT3 TPST1 TPST2
Entrez ID		6358	1230
HPRD ID		03231	03101
Ensembl ID		ENSG00000213494	ENSG00000163823
Uniprot IDs		Q16627	P32246 Q5U003
PDB IDs		2Q8R 2Q8T	1Y5D
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cellular Response To Organic Substance Inflammatory Response Cytokine-mediated Signaling Pathway Dendritic Cell Chemotaxis Locomotion Cellular Chemical Homeostasis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Defense Response Cellular Response To Cytokine Stimulus Chemotaxis Cytosolic Calcium Ion Homeostasis Dendritic Cell Migration Cellular Homeostasis Response To Cytokine Leukocyte Migration Cell Surface Receptor Signaling Pathway Positive Regulation Of Glucose Import Chemical Homeostasis Positive Regulation Of Glucose Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Establishment Of Localization In Cell Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Cellular Defense Response Positive Regulation Of Locomotion Regulation Of Glucose Import Regulation Of Osteoclast Differentiation Cellular Metal Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Cellular Localization Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Immune Response Regulation Of Glucose Transport NFAT Protein Import Into Nucleus Homeostatic Process Viral Process Leukocyte Chemotaxis Ion Homeostasis Regulation Of Myeloid Leukocyte Differentiation Transport Regulation Of Cell Migration Intracellular Transport Transcription Factor Import Into Nucleus Regulation Of Cell Motility Signal Transduction	Cell Chemotaxis Chemotaxis Inflammatory Response Locomotion Cell Migration Cell Motility Immune Response Defense Response Response To External Stimulus Movement Of Cell Or Subcellular Component Monocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Cellular Calcium Ion Homeostasis Immune System Process Calcium Ion Homeostasis Positive Regulation Of Leukocyte Migration Response To Stress Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Chemical Homeostasis Cellular Metal Ion Homeostasis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Chemotaxis Regulation Of Behavior Positive Regulation Of Cellular Component Movement Ion Homeostasis Positive Regulation Of Locomotion Cellular Response To Stimulus Positive Regulation Of Calcium Ion Transport Regulation Of Cell Migration Cell-cell Signaling Regulation Of Cell Motility Leukocyte Chemotaxis Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Eosinophil Chemotaxis Regulation Of Locomotion Homeostatic Process Regulation Of Cellular Component Movement Eosinophil Migration Cellular Homeostasis
Tagcloud ?		17f 28a 6ckine ccl13 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		17f 28a 6ckine ccl13 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?