CCL11 and ACKR2

Number of citations of the paper that reports this interaction (PMID 9405404)
30

Data Source:
HPRD (in vivo)

		CCL11	ACKR2
Gene Name		chemokine (C-C motif) ligand 11	atypical chemokine receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Early Endosome Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome
	Molecular Function	Protein Binding Chemokine Activity	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction Regulation Of Cell Shape Response To Radiation Response To Virus Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Rac GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth ERK1 And ERK2 Cascade Response To Interleukin-4	Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Neutrophil Activation Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: ACKR2 ACKR4 CCR3 CCR5 DPP4 NUDT3 TPI1	16 interactors: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8
Entrez ID		6356	1238
HPRD ID		03098	09095
Ensembl ID		ENSG00000172156	ENSG00000144648
Uniprot IDs		P51671 Q6I9T4	O00590
PDB IDs		1EOT 2EOT
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Locomotion Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Cellular Defense Response G-protein Coupled Receptor Signaling Pathway Inflammatory Response Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Organophosphate Catabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To External Stimulus Cellular Response To Organic Substance Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Cytosolic Calcium Ion Homeostasis Immune System Process Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cell-cell Adhesion Mediated By Integrin Cellular Calcium Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Homeostasis Response To Organic Substance Dendritic Cell Chemotaxis Receptor-mediated Endocytosis Immune Response Defense Response Cellular Metal Ion Homeostasis Neutrophil Activation Cellular Cation Homeostasis Response To Cholesterol Cellular Ion Homeostasis Dendritic Cell Migration Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Cell Surface Receptor Signaling Pathway Metal Ion Homeostasis Leukocyte Activation Regulation Of Extracellular Matrix Disassembly Cellular Chemical Homeostasis Signaling Viral Process Response To Stress Glucose 6-phosphate Metabolic Process Release Of Sequestered Calcium Ion Into Cytosol Ion Homeostasis Cell Communication Nucleotide Metabolic Process	Cell Chemotaxis Chemotaxis Cell Migration Locomotion Immune Response Cell Motility Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Immune System Process Ion Homeostasis Cellular Homeostasis Leukocyte Chemotaxis Eosinophil Chemotaxis Leukocyte Migration Chemical Homeostasis Eosinophil Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Defense Response Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Cell Migration Positive Regulation Of Behavior Regulation Of Cell Motility Granulocyte Chemotaxis Regulation Of Chemotaxis Homeostatic Process Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Behavior Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Monocyte Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Migration Cellular Response To Stimulus Response To Stress Regulation Of Granulocyte Chemotaxis
Tagcloud ?		biopsy ccl5 cells chemokines chemotaxins compare cx3cl1 determined distribution epithelial il immunohistochemistry included intraepithelial investigate mast method might migrate migration mucosa nasal normal objective obtained polyps regulated result specimens
Tagcloud (Difference) ?		biopsy ccl5 cells chemokines chemotaxins compare cx3cl1 determined distribution epithelial il immunohistochemistry included intraepithelial investigate mast method might migrate migration mucosa nasal normal objective obtained polyps regulated result specimens
Tagcloud (Intersection) ?