SCN4B and SCN2A

Number of citations of the paper that reports this interaction (PMID 12930796)
82

Data Source:
HPRD (in vivo, in vitro)

		SCN4B	SCN2A
Gene Name		sodium channel, voltage gated, type IV beta subunit	sodium channel, voltage gated, type II alpha subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Intercalated Disc Intrinsic Component Of Plasma Membrane	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex
	Molecular Function	Voltage-gated Sodium Channel Activity Sodium Channel Regulator Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential	Voltage-gated Sodium Channel Activity
	Biological Process	Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Sodium Ion Transmembrane Transport Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Sodium Ion Transport Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Membrane Depolarization During Action Potential
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: SCN2A	5 interactors: ANK3 ARHGEF10L MPP3 RNF130 SCN4B
Entrez ID		6330	6326
HPRD ID		09749	03133
Ensembl ID		ENSG00000177098	ENSG00000136531
Uniprot IDs		B0YJ93 Q8IWT1	Q99250
PDB IDs			2KAV
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Osmotic Stress Neuronal Action Potential Membrane Depolarization During Action Potential Neuron Apoptotic Process Transmission Of Nerve Impulse Neuron Death Action Potential Response To Osmotic Stress Membrane Depolarization Myelination Axon Ensheathment Intrinsic Apoptotic Signaling Pathway Sodium Ion Transmembrane Transport Sodium Ion Transport Regulation Of Membrane Potential Apoptotic Signaling Pathway Regulation Of Ion Transmembrane Transport	Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Regulation Of Sodium Ion Transport Action Potential Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Ion Transport Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cellular Response To Magnesium Ion Regulation Of Membrane Depolarization During Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Action Potential Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Cytoskeletal Anchoring At Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization SREBP Signaling Pathway Regulation Of Actin Filament-based Process Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Response To Sterol Depletion Positive Regulation Of Sodium Ion Transmembrane Transport Magnesium Ion Homeostasis Response To Magnesium Ion Negative Regulation Of Cation Channel Activity Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Membrane Assembly Regulation Of Heart Rate By Cardiac Conduction Golgi To Plasma Membrane Protein Transport Membrane Biogenesis Neuronal Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Protein Targeting To Membrane Regulation Of Ion Transport Golgi To Plasma Membrane Transport Membrane Depolarization During Action Potential Regulation Of Membrane Depolarization Cardiac Muscle Cell Action Potential
Tagcloud ?			16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications spasms stxbp1 xq28
Tagcloud (Difference) ?			16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications spasms stxbp1 xq28
Tagcloud (Intersection) ?