SCN2A and ANK3

Number of citations of the paper that reports this interaction (PMID 12036953)
12

Data Source:
HPRD (in vivo)

		SCN2A	ANK3
Gene Name		sodium channel, voltage gated, type II alpha subunit	ankyrin 3, node of Ranvier (ankyrin G)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex	Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Dendrite Neuromuscular Junction Node Of Ranvier Paranode Region Of Axon Sarcolemma Costamere Axon Initial Segment Postsynaptic Membrane
	Molecular Function	Voltage-gated Sodium Channel Activity	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding Cadherin Binding
	Biological Process	Sodium Ion Transport Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Membrane Depolarization During Action Potential	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeletal Anchoring At Plasma Membrane Signal Transduction Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Protein Targeting To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 22182935 21926972 18711365) Bipolar disorder and major depressive disorder (combined) ( 20351715) Schizophrenia ( 20185149)
Protein-Protein Interactions		5 interactors: ANK3 ARHGEF10L MPP3 RNF130 SCN4B	12 interactors: FADD FAS HOOK1 KCNC1 MAPK6 PIK3R1 SCN1B SCN2A SCNN1B SMAD2 SMAD3 SPTBN4
Entrez ID		6326	288
HPRD ID		03133	02715
Ensembl ID		ENSG00000136531	ENSG00000151150
Uniprot IDs		Q99250	Q12955 Q8NAK2
PDB IDs		2KAV
Enriched GO Terms of Interacting Partners?		Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Regulation Of Sodium Ion Transport Action Potential Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Ion Transport Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cellular Response To Magnesium Ion Regulation Of Membrane Depolarization During Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Action Potential Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Cytoskeletal Anchoring At Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization SREBP Signaling Pathway Regulation Of Actin Filament-based Process Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Response To Sterol Depletion Positive Regulation Of Sodium Ion Transmembrane Transport Magnesium Ion Homeostasis Response To Magnesium Ion Negative Regulation Of Cation Channel Activity Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Membrane Assembly Regulation Of Heart Rate By Cardiac Conduction Golgi To Plasma Membrane Protein Transport Membrane Biogenesis Neuronal Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Protein Targeting To Membrane Regulation Of Ion Transport Golgi To Plasma Membrane Transport Membrane Depolarization During Action Potential Regulation Of Membrane Depolarization Cardiac Muscle Cell Action Potential	Extrinsic Apoptotic Signaling Pathway Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Neuron Apoptotic Process Transmission Of Nerve Impulse Necroptotic Signaling Pathway Primary MiRNA Processing Neuron Death SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Communication Nodal Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Embryonic Foregut Morphogenesis Positive Regulation Of Endopeptidase Activity Lymphocyte Activation Foregut Morphogenesis Paraxial Mesoderm Development Positive Regulation Of Peptidase Activity Cell Differentiation Regulation Of Cell Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organismal Development Pericardium Development Apoptotic Process Leukocyte Activation Anatomical Structure Development Programmed Cell Death Regulation Of Myeloid Cell Differentiation Signal Transduction Involved In Regulation Of Gene Expression Transport Protein Complex Assembly Cell Death Death Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Necroptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Abiotic Stimulus Sodium Ion Transmembrane Transport Regulation Of Cysteine-type Endopeptidase Activity Gene Silencing By MiRNA Membrane Depolarization During Action Potential
Tagcloud ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications spasms stxbp1 xq28	add adipocytes algorithms backward bd bipolar categorical chi2 contingency doi escitalopram expand lithium meaningful mp ordinal pkc psychiatry publication remove rs10761482 snp stepwise suffer swedish switches tables takes variance
Tagcloud (Difference) ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications spasms stxbp1 xq28	add adipocytes algorithms backward bd bipolar categorical chi2 contingency doi escitalopram expand lithium meaningful mp ordinal pkc psychiatry publication remove rs10761482 snp stepwise suffer swedish switches tables takes variance
Tagcloud (Intersection) ?