SBF1 and MTMR2

Number of citations of the paper that reports this interaction (PMID 12668758)
29

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		SBF1	MTMR2
Gene Name		SET binding factor 1	myotubularin related protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Integral Component Of Membrane	Nucleus Cytoplasm Vacuolar Membrane Cytosol Synaptic Vesicle Axon Dendrite Early Endosome Membrane Dendritic Spine Extracellular Vesicular Exosome Synaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Protein Tyrosine/serine/threonine Phosphatase Activity Rab Guanyl-nucleotide Exchange Factor Activity	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Homodimerization Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Protein Dephosphorylation Spermatogenesis Positive Regulation Of Rab GTPase Activity	Negative Regulation Of Receptor Internalization Protein Dephosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Peptidyl-tyrosine Dephosphorylation Small Molecule Metabolic Process Negative Regulation Of Endocytosis Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Neuron Development Protein Tetramerization Negative Regulation Of Excitatory Postsynaptic Membrane Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process
Pathways			Synthesis of PIPs at the early endosome membrane Metabolism of lipids and lipoproteins Phospholipid metabolism Synthesis of PIPs at the late endosome membrane PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: KMT2A MTMR2 PDPK1 SUV39H1 TNFSF11	3 interactors: NEFL SBF1 SNTA1
Entrez ID		6305	8898
HPRD ID		06788	04650
Ensembl ID		ENSG00000100241	ENSG00000087053
Uniprot IDs		G5E933 O95248	Q13614
PDB IDs			1LW3 1M7R 1ZSQ 1ZVR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Peptidyl-lysine Trimethylation Histone Lysine Methylation Peptidyl-lysine Methylation Cellular Component Assembly Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Cellular Response To Drug Histone Methylation Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling TNFSF11-mediated Signaling Pathway Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Protein Modification Process Protein Methylation Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Peptidyl-amino Acid Modification Developmental Process Positive Regulation Of Ion Transport Positive Regulation Of T Cell Activation Protein Complex Assembly Regulation Of Cellular Localization Regulation Of Gene Expression, Epigenetic Positive Regulation Of Osteoclast Development Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Response To Drug Osteoclast Proliferation Positive Regulation Of Intracellular Transport Positive Regulation Of Cell-cell Adhesion Peptidyl-lysine Modification Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Histone H3-K9 Dimethylation Negative Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of T Cell Activation Regulation Of Osteoclast Development Cellular Protein Modification Process Positive Regulation Of Cell Activation Rhythmic Process Dendritic Spine Maintenance Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Receptor Internalization Negative Regulation Of Myelination Cell Differentiation Positive Regulation Of Fever Generation Regulation Of Fever Generation	Regulation Of Vasoconstriction By Circulating Norepinephrine Neurofilament Bundle Assembly Negative Regulation Of Peptidyl-cysteine S-nitrosylation Intermediate Filament Bundle Assembly Axon Transport Of Mitochondrion Regulation Of Axon Diameter Regulation Of Cell Projection Size Retrograde Axon Cargo Transport Peripheral Nervous System Axon Regeneration Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Neurofilament Cytoskeleton Organization Intermediate Filament Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Anterograde Axon Cargo Transport Cardiac Muscle Cell Action Potential Involved In Contraction Response To Corticosterone Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Response To Mineralocorticoid Intermediate Filament Cytoskeleton Organization Axon Regeneration Intermediate Filament-based Process Regulation Of Cardiac Muscle Cell Contraction Neuron Projection Regeneration Axon Cargo Transport Neuromuscular Junction Development Regulation Of Vasoconstriction
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