MTMR2

Gene Name		myotubularin related protein 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Vacuolar Membrane Cytosol Synaptic Vesicle Axon Dendrite Early Endosome Membrane Dendritic Spine Extracellular Vesicular Exosome Synaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Homodimerization Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Negative Regulation Of Receptor Internalization Protein Dephosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Peptidyl-tyrosine Dephosphorylation Small Molecule Metabolic Process Negative Regulation Of Endocytosis Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Neuron Development Protein Tetramerization Negative Regulation Of Excitatory Postsynaptic Membrane Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process
Pathways		Synthesis of PIPs at the early endosome membrane Metabolism of lipids and lipoproteins Phospholipid metabolism Synthesis of PIPs at the late endosome membrane PI Metabolism
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: NEFL SBF1 SNTA1
Entrez ID		8898
HPRD ID		04650
Ensembl ID		ENSG00000087053
Uniprot IDs		Q13614
PDB IDs		1LW3 1M7R 1ZSQ 1ZVR
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction By Circulating Norepinephrine Neurofilament Bundle Assembly Negative Regulation Of Peptidyl-cysteine S-nitrosylation Intermediate Filament Bundle Assembly Axon Transport Of Mitochondrion Regulation Of Axon Diameter Regulation Of Cell Projection Size Retrograde Axon Cargo Transport Peripheral Nervous System Axon Regeneration Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Neurofilament Cytoskeleton Organization Intermediate Filament Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Anterograde Axon Cargo Transport Cardiac Muscle Cell Action Potential Involved In Contraction Response To Corticosterone Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Response To Mineralocorticoid Intermediate Filament Cytoskeleton Organization Axon Regeneration Intermediate Filament-based Process Regulation Of Cardiac Muscle Cell Contraction Neuron Projection Regeneration Axon Cargo Transport Neuromuscular Junction Development Regulation Of Vasoconstriction
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