S100A11 and S100B

Number of citations of the paper that reports this interaction (PMID 10913138)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		S100A11	S100B
Gene Name		S100 calcium binding protein A11	S100 calcium binding protein B
Image
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Space Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Signal Transduction Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs			Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
Diseases
GWAS			Lymphocyte counts ( 22286170)
Protein-Protein Interactions		4 interactors: ACTB ANXA1 NCL S100B	27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1
Entrez ID		6282	6285
HPRD ID		04385	01505
Ensembl ID		ENSG00000163191
Uniprot IDs		P31949	P04271
PDB IDs		1V4Z 1V50 2LUC	1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM
Enriched GO Terms of Interacting Partners?		Neutrophil Clearance Response To Glucocorticoid Response To Corticosteroid DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Negative Regulation Of Phospholipase A2 Activity Gliogenesis Negative Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of Interleukin-8 Secretion Defense Response Prolactin Secretion Positive Regulation Of Prostaglandin Biosynthetic Process System Development Negative Regulation Of Phospholipase Activity Homotypic Cell-cell Adhesion Neurogenesis Positive Regulation Of Myeloid Cell Apoptotic Process Response To Methylmercury Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Phospholipase A2 Activity Anatomical Structure Development DNA Strand Renaturation Arachidonic Acid Secretion Positive Regulation Of Fatty Acid Biosynthetic Process Response To Steroid Hormone Negative Regulation Of Interleukin-8 Production Regulation Of Interleukin-8 Secretion Neutrophil Homeostasis Hepatocyte Differentiation Immune System Process Single Organismal Cell-cell Adhesion Axonogenesis Developmental Process Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Transcription From RNA Polymerase I Promoter Axon Development Negative Regulation Of Lipase Activity Nervous System Development Negative Regulation Of Skeletal Muscle Tissue Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Vesicle Fusion Positive Regulation Of Programmed Cell Death Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Death Anatomical Structure Morphogenesis Positive Regulation Of Cell Cycle G1/S Phase Transition Neuron Projection Morphogenesis	Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		a2 abstract accumulates annexin annexins ca2 constant cytoskeleton damaged depending ef entry environment harsh imposed initiates injured metastatic motility organelles partner pm pmr repair respond stresses stroma	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Difference) ?		a2 abstract accumulates annexin annexins ca2 constant cytoskeleton damaged depending ef entry environment harsh imposed initiates injured metastatic motility organelles partner pm pmr repair respond stresses stroma	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Intersection) ?