S100B and CAPZA1

Number of citations of the paper that reports this interaction (PMID 12470955)
29

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		S100B	CAPZA1
Gene Name		S100 calcium binding protein B	capping protein (actin filament) muscle Z-line, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Extracellular Region Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Extracellular Vesicular Exosome WASH Complex
	Molecular Function	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Actin Binding Protein Binding
	Biological Process	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation	Protein Complex Assembly Movement Of Cell Or Subcellular Component Blood Coagulation Innate Immune Response Barbed-end Actin Filament Capping
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Factors involved in megakaryocyte development and platelet production Advanced glycosylation endproduct receptor signaling Innate Immune System
Drugs		Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
Diseases
GWAS		Lymphocyte counts ( 22286170)	Blood pressure ( 21572416)
Protein-Protein Interactions		27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1	7 interactors: ACTB CD2AP HSPA8 S100A1 S100B SH3KBP1 UCHL5
Entrez ID		6285	829
HPRD ID		01505	03347
Ensembl ID			ENSG00000116489
Uniprot IDs		P04271	P52907
PDB IDs		1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM	1MQ1 1MWN
Enriched GO Terms of Interacting Partners?		Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway	Midbrain Development Substantia Nigra Development 'de Novo' Posttranslational Protein Folding Central Nervous System Development 'de Novo' Protein Folding Neural Nucleus Development Cellular Response To Stimulus Nervous System Development Cell Projection Organization Locomotion Negative Regulation Of Fibril Organization Axonogenesis Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Voltage-gated Calcium Channel Activity Response To Stimulus Neuron Projection Morphogenesis Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Fibril Organization Cell Morphogenesis Involved In Differentiation Regulation Of Cell Shape Signaling Brain Development Negative Regulation Of Skeletal Muscle Cell Differentiation Cell Communication Head Development Regulation Of Cellular Component Organization Neuron Projection Development Clathrin Coat Disassembly Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Production Enzyme Linked Receptor Protein Signaling Pathway Neuron Development System Development Cell Morphogenesis Protein Folding Anatomical Structure Morphogenesis Response To Methylmercury Neuron Differentiation Substrate-dependent Cell Migration, Cell Extension Multicellular Organismal Development Axon Guidance Anatomical Structure Development Regulation Of Skeletal Muscle Cell Differentiation Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Refolding
Tagcloud ?		accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized	cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays mrpl20 rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6
Tagcloud (Difference) ?		accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized	cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays mrpl20 rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6
Tagcloud (Intersection) ?