RPS15 and RAPGEF1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RPS15	RAPGEF1
Gene Name		ribosomal protein S15	Rap guanine nucleotide exchange factor (GEF) 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit	Endosome Early Endosome Cytosol
	Molecular Function	DNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding	Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity SH3 Domain Binding
	Biological Process	Ribosomal Small Subunit Assembly Ribosomal Small Subunit Export From Nucleus Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Osteoblast Differentiation RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Ribosomal Small Subunit Biogenesis Cellular Protein Metabolic Process	Activation Of MAPKK Activity Blood Vessel Development Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Neuron Projection Development Single Organismal Cell-cell Adhesion Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: G2E3 PLA2G12A RAPGEF1 RPS4X SERINC3 UPF2	16 interactors: ABL1 ATXN1 BCAR1 CRK CRKL GRB2 HCK HRAS MBIP NEDD9 RAP1B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID		6209	2889
HPRD ID		01613	02627
Ensembl ID		ENSG00000115268	ENSG00000107263
Uniprot IDs		K7ELC2 K7EM56 P62841	Q13905 Q68DL3
PDB IDs		2ZKQ 3J3A
Enriched GO Terms of Interacting Partners?		Phosphatidylserine Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway MRNA Catabolic Process RNA Catabolic Process	Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Response To Organonitrogen Compound Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Hemostasis Response To Peptide Hormone Immune Response-regulating Signaling Pathway Response To Peptide Fc Receptor Signaling Pathway Response To Insulin Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway Wound Healing Small GTPase Mediated Signal Transduction Response To Growth Factor ERBB Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Signal Transduction Platelet Activation Regulation Of Actin Filament-based Process Response To Wounding Cell Communication Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization Regulation Of Immune Response Response To Organic Substance Signal Transduction
Tagcloud ?		abcg2 accepted actb b2m colostrum correct dgat1 elf5 errors gapdh geometric gtp incurred lactating lactation milk mrpl39 normalization ppp1r11 reference rn18s1 rps9 somatic srebf2 steps thereafter uxt yak yaks	abl abrogated c3g catalytically colocalized crk delineate dephosphorylation forskolin golgi guanine imr interacted neurite neuroblastoma noncatalytic outgrowth pc3g pervanadate phospho ptp ptpn2 reorganization src substrate tc tc48 vanadate y504
Tagcloud (Difference) ?		abcg2 accepted actb b2m colostrum correct dgat1 elf5 errors gapdh geometric gtp incurred lactating lactation milk mrpl39 normalization ppp1r11 reference rn18s1 rps9 somatic srebf2 steps thereafter uxt yak yaks	abl abrogated c3g catalytically colocalized crk delineate dephosphorylation forskolin golgi guanine imr interacted neurite neuroblastoma noncatalytic outgrowth pc3g pervanadate phospho ptp ptpn2 reorganization src substrate tc tc48 vanadate y504
Tagcloud (Intersection) ?