RAPGEF1 and BCAR1

Number of citations of the paper that reports this interaction (PMID 9748234)
22

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		RAPGEF1	BCAR1
Gene Name		Rap guanine nucleotide exchange factor (GEF) 1	breast cancer anti-estrogen resistance 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Cytosol	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium
	Molecular Function	Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity SH3 Domain Binding	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Neuron Projection Development Single Organismal Cell-cell Adhesion Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis
Pathways		Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation	Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		16 interactors: ABL1 ATXN1 BCAR1 CRK CRKL GRB2 HCK HRAS MBIP NEDD9 RAP1B RHOQ RPS15 RRAS2 SHC1 SLC20A1	52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ
Entrez ID		2889	9564
HPRD ID		02627	04248
Ensembl ID		ENSG00000107263	ENSG00000050820
Uniprot IDs		Q13905 Q68DL3	B2RBL9 B3KWE2 F5H855 P56945
PDB IDs			1WYX 3T6G
Enriched GO Terms of Interacting Partners?		Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Response To Organonitrogen Compound Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Hemostasis Response To Peptide Hormone Immune Response-regulating Signaling Pathway Response To Peptide Fc Receptor Signaling Pathway Response To Insulin Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway Wound Healing Small GTPase Mediated Signal Transduction Response To Growth Factor ERBB Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Signal Transduction Platelet Activation Regulation Of Actin Filament-based Process Response To Wounding Cell Communication Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization Regulation Of Immune Response Response To Organic Substance Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling
Tagcloud ?		abl abrogated c3g catalytically colocalized crk delineate dephosphorylation forskolin golgi guanine imr interacted neurite neuroblastoma noncatalytic outgrowth pc3g pervanadate phospho ptp ptpn2 reorganization src substrate tc tc48 vanadate y504	aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		abl abrogated c3g catalytically colocalized crk delineate dephosphorylation forskolin golgi guanine imr interacted neurite neuroblastoma noncatalytic outgrowth pc3g pervanadate phospho ptp ptpn2 reorganization src substrate tc tc48 vanadate y504	aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?