RPN2 and FBN3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RPN2	FBN3
Gene Name		ribophorin II	fibrillin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Autophagic Vacuole Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane	Proteinaceous Extracellular Matrix
	Molecular Function	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Ribosome Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding
	Biological Process	Translation Cellular Protein Modification Process SRP-dependent Cotranslational Protein Targeting To Membrane Aging Gene Expression Protein N-linked Glycosylation Via Asparagine Response To Drug Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Translation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification SRP-dependent cotranslational protein targeting to membrane Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)	Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		8 interactors: ADRM1 EZH2 FBN3 NDRG1 NGFR RBBP4 RCHY1 RHOA	13 interactors: ANXA7 BID C11orf58 CDKN1A DAZAP2 GADD45A GSK3B NUDT21 PIK3R3 RPN2 RPS6KA6 TK1 TSC22D1
Entrez ID		6185	84467
HPRD ID		01609	10538
Ensembl ID		ENSG00000118705	ENSG00000142449
Uniprot IDs		P04844	Q75N90
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Axonogenesis Regulation Of Epidermis Development Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Axonogenesis Regulation Of Cell Morphogenesis Regulation Of Cell Cycle Process Positive Regulation Of Cell Development Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Neurogenesis Regulation Of Proteolysis Negative Regulation Of Cell Projection Organization Regulation Of Neurogenesis Negative Regulation Of Hair Follicle Development Skeletal Muscle Satellite Cell Migration Regulation Of Axonogenesis Negative Regulation Of Cell Differentiation Negative Regulation Of Hair Cycle Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Neuron Differentiation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Regulation Of Gene Expression, Epigenetic Neurotrophin TRK Receptor Signaling Pathway Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Positive Regulation Of Spindle Checkpoint Cleavage Furrow Formation Regulation Of Protein Metabolic Process Central Nervous System Development Nervous System Development G1 To G0 Transition Protein Complex Assembly Cell Cycle Process DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Negative Regulation Of Epidermal Cell Differentiation Positive Regulation Of Cell Cycle Checkpoint Proteasome Assembly Histone H3-K27 Methylation Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process	Signal Transduction In Response To DNA Damage Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Protein Kinase Activity Positive Regulation Of Apoptotic Process Negative Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Mitochondrion Organization Cellular Response To Ionizing Radiation Negative Regulation Of Transferase Activity Regulation Of Apoptotic Process Negative Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Response To Metal Ion Fetal Process Involved In Parturition Cellular Response To Stress Regulation Of Cell Death Apoptotic Signaling Pathway Cellular Response To DNA Damage Stimulus Cellular Response To Mechanical Stimulus Response To Organic Substance Response To Organic Cyclic Compound DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Hormone Regulation Of Mitochondrion Organization Negative Regulation Of Type B Pancreatic Cell Development Skeletal Muscle Cell Proliferation Superior Temporal Gyrus Development Apoptotic Process Protein Oligomerization Regulation Of Intracellular Transport Programmed Cell Death Protein Tetramerization Extrinsic Apoptotic Signaling Pathway Response To External Stimulus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Death Death Phosphorylation Intracellular Signal Transduction Response To Heat Signal Transduction By P53 Class Mediator Response To Inorganic Substance Re-entry Into Mitotic Cell Cycle
Tagcloud ?		acc1 adp1 aids albicans antiretroviral candida candidiasis decades diploid divergence epidemiology fluconazole gln4 haart heterozygous immunocompromised iran iranian isolate loci mlst multilocus phylogeny polymorphic scheme sya1 typed typing vps13
Tagcloud (Difference) ?		acc1 adp1 aids albicans antiretroviral candida candidiasis decades diploid divergence epidemiology fluconazole gln4 haart heterozygous immunocompromised iran iranian isolate loci mlst multilocus phylogeny polymorphic scheme sya1 typed typing vps13
Tagcloud (Intersection) ?