RPL31 and CACNA1A

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		RPL31	CACNA1A
Gene Name		ribosomal protein L31	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Image
Gene Ontology Annotations	Cellular Component	Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Dendrite Cell Projection Neuronal Cell Body
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Sulfur Amino Acid Metabolic Process Glucose Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Neuromuscular Synaptic Transmission Synapse Assembly Adult Walking Behavior Cell Death Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Cell Growth Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Transmission Of Nerve Impulse Spinal Cord Motor Neuron Differentiation Cerebellum Maturation Cerebellar Molecular Layer Development Cerebellar Purkinje Cell Differentiation Vestibular Nucleus Development Cellular Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Regulation Of Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Neurotransmitter Metabolic Process Hormone Metabolic Process Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Behavioral Response To Pain Calcium Ion-dependent Exocytosis Of Neurotransmitter Dendrite Morphogenesis Regulation Of Axonogenesis Regulation Of Insulin Secretion Musculoskeletal Movement, Spinal Reflex Action Neuromuscular Process Controlling Balance Membrane Depolarization Rhythmic Synaptic Transmission Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Integration of energy metabolism Regulation of insulin secretion Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs			Pregabalin Verapamil Loperamide Bepridil
Diseases
GWAS
Protein-Protein Interactions		8 interactors: APP BLVRB BRCA1 CACNA1A CRKL EWSR1 GPR20 IL7R	92 interactors: ABCA2 ABI1 ACTN1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 ASNA1 BTG3 BZRAP1 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LPHN1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TUBB2B UQCRC2 VARS VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		6160	773
HPRD ID		17994	03004
Ensembl ID		ENSG00000071082	ENSG00000141837
Uniprot IDs		B7Z4C8 B7Z4E3 P62899	B5TYJ1 O00555 Q9NS89
PDB IDs		3J3B	3BXK
Enriched GO Terms of Interacting Partners?		Cell Growth Neuromuscular Process Controlling Balance Synapse Assembly Positive Regulation Of Histone H4-K20 Methylation Cerebellar Molecular Layer Development Positive Regulation Of Histone H4-K16 Acetylation Growth Adult Locomotory Behavior Vestibular Nucleus Development Synaptic Growth At Neuromuscular Junction Positive Regulation Of Histone H3-K9 Acetylation Interleukin-7-mediated Signaling Pathway Neuromuscular Process Dendrite Development Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Collateral Sprouting In Absence Of Injury Gamma-aminobutyric Acid Secretion Adult Behavior Synapse Organization Cell Surface Receptor Signaling Pathway Cellular Response To Indole-3-methanol Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Acetylcholine Secretion, Neurotransmission Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Centriole Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Rhythmic Synaptic Transmission Intracellular Receptor Signaling Pathway Signal Transduction Dosage Compensation By Inactivation Of X Chromosome Axon Choice Point Recognition Positive Regulation Of Cell Cycle Process Protein K6-linked Ubiquitination Heme Catabolic Process Locomotory Behavior Cellular Chloride Ion Homeostasis Regulation Of Histone H3-K9 Acetylation Calcium Ion-dependent Exocytosis Of Neurotransmitter Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Chloride Ion Homeostasis Neuron Remodeling Gamma-aminobutyric Acid Transport Signaling Parathyroid Gland Development	Secretion By Cell Secretion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Voltage-gated Calcium Channel Activity Detection Of Visible Light Enzyme Linked Receptor Protein Signaling Pathway Detection Of Light Stimulus Multicellular Organismal Development Phototransduction, Visible Light Anatomical Structure Development Cellular Localization Axon Development Developmental Process Establishment Of Localization In Cell Phototransduction Regulation Of Cellular Process System Development Axonogenesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Detection Of Abiotic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Degranulation Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Regulation Of Cation Channel Activity Axon Guidance Nervous System Development Detection Of Calcium Ion Regulation Of Intracellular Cholesterol Transport Regulation Of Cell Communication By Electrical Coupling Neuron Projection Morphogenesis Exocytosis Neuron Projection Development Cellular Response To Growth Factor Stimulus Neuron Differentiation Inositol Phosphate Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Cell Part Morphogenesis Response To Growth Factor Cell Surface Receptor Signaling Pathway Negative Regulation Of Cation Channel Activity Platelet Activation Cell-cell Signaling Nerve Growth Factor Processing Pathogenesis Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		abcc5 akt1 albeit behalf britain crnde drivers dynl11 exome harboured hotspot ireland john journal k700e ltd mucinous perturbation sf3b sf3b1 sons spliceosomal spliceostatin splicing tmem14c unselected uqcc uveal wiley	acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage
Tagcloud (Difference) ?		abcc5 akt1 albeit behalf britain crnde drivers dynl11 exome harboured hotspot ireland john journal k700e ltd mucinous perturbation sf3b sf3b1 sons spliceosomal spliceostatin splicing tmem14c unselected uqcc uveal wiley	acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage
Tagcloud (Intersection) ?