RPL13 and UPF2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		RPL13	UPF2
Gene Name		ribosomal protein L13	UPF2 regulator of nonsense transcripts homolog (yeast)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Gene Expression Organ Regeneration
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		16 interactors: ANXA7 CEP70 CSNK2A1 CSNK2B DAXX ILK IPO5 MAP2K3 MAPKAPK5 RAD21 RELA SMN1 SPP1 TERF2 TK1 UPF2	75 interactors: ABCF2 AGPAT1 ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 GLTSCR2 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MYB NDUFA7 NOB1 NOMO1 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SKIV2L2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		6137	26019
HPRD ID		06428	10405
Ensembl ID		ENSG00000167526	ENSG00000151461
Uniprot IDs		A8K4C8 P26373	Q9HAU5
PDB IDs		3J3B	1UW4 2WJV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Cell Cycle Cell Aging Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Aging Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Mitotic Cell Cycle Phosphorylation Activation Of MAPK Activity Response To Stress Regulation Of Kinase Activity Developmental Process Positive Regulation Of Intracellular Signal Transduction Liver Development Response To Stimulus Protein Localization To Chromosome Positive Regulation Of MAPK Cascade Cellular Senescence Positive Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Cellular Response To Stress Anatomical Structure Development Positive Regulation Of Transferase Activity MAPK Cascade Cell Cycle Process Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 10 Signaling Pathway Regulation Of MAPK Cascade Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Fetal Process Involved In Parturition Acetaldehyde Metabolic Process Positive Regulation Of Metabolic Process Activation Of Protein Kinase Activity Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Signal Transduction By Phosphorylation	Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process Gene Expression Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Histone MRNA Catabolic Process RRNA Processing Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Translational Initiation Viral Process Ribosome Biogenesis Biosynthetic Process Histone MRNA Metabolic Process Cellular Metabolic Process Translational Termination Protein Complex Disassembly Translational Elongation RNA Biosynthetic Process Ribonucleoprotein Complex Biogenesis Cellular Protein Complex Disassembly Viral Transcription NcRNA Metabolic Process SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Metabolic Process Establishment Of Protein Localization To Membrane Translation Protein Targeting To Membrane Nuclear MRNA Surveillance Protein Localization To Membrane
Tagcloud ?		30s 5a 60s amongst atub bestkeeper cyp ef foundation gapdh genorm ginseng housekeeping iia ingredients medicines normalization normfinder optimum panax popular qcr qrt ranked reference rps20 sar1 stems transcriptomics	achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi
Tagcloud (Difference) ?		30s 5a 60s amongst atub bestkeeper cyp ef foundation gapdh genorm ginseng housekeeping iia ingredients medicines normalization normfinder optimum panax popular qcr qrt ranked reference rps20 sar1 stems transcriptomics	achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi
Tagcloud (Intersection) ?