RPA1 and RAD51

Number of citations of the paper that reports this interaction (PMID 12077133)
63

Data Source:
HPRD (in vitro, in vivo)

		RPA1	RAD51
Gene Name		replication protein A1, 70kDa	RAD51 recombinase
Image
Gene Ontology Annotations	Cellular Component	Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body	Nuclear Chromosome Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Microtubule Organizing Center PML Body Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Metal Ion Binding	Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding Identical Protein Binding Single-stranded DNA-dependent ATPase Activity DNA Polymerase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly In Utero Embryonic Development DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair DNA Recombination Meiotic Nuclear Division Positive Regulation Of Cell Proliferation Hemopoiesis Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Homeostasis Of Number Of Cells Within A Tissue Regulation Of Cellular Response To Heat	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Unwinding Involved In DNA Replication DNA Repair Double-strand Break Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus Meiotic Nuclear Division Reciprocal Meiotic Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Ligation Protein Homooligomerization Cellular Response To Ionizing Radiation Cellular Response To Camptothecin
Pathways		HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints	Assembly of the RAD51-ssDNA nucleoprotein complex Homologous DNA pairing and strand exchange Meiotic recombination Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS
Protein-Protein Interactions		63 interactors: AICDA AKTIP ANXA1 ANXA7 ASCC2 ATM ATRIP BID BLM BRCA2 BRIP1 CCNA1 CCNA2 CCNB1 CDC5L CDK1 CDK2 CPE CSNK2B DMC1 EXO5 GNB5 HAX1 HELB HGH1 HNRNPUL1 HUS1 MCM2 MCM4 MCM6 MCM7 MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRKDC PRPF19 RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RCC1 RECQL RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WRN XPA XPC	42 interactors: ABL1 ATM ATRX BCCIP BLM BRCA1 BRCA2 CASP3 CASP7 CHD3 CHEK1 DMC1 DNAJA3 ERCC2 FANCD2 FBXO18 HID1 HNRNPC IRS1 MDC1 NXF1 PFN1 RAD18 RAD51AP1 RAD51AP2 RAD51C RAD52 RAD54B RAD54L RPA1 RPA3 SFR1 SUMO1 SWI5 SWSAP1 TP53 UBE2I UGDH UHRF2 VIM WRN ZDHHC17
Entrez ID		6117	5888
HPRD ID		01565	01557
Ensembl ID		ENSG00000132383	ENSG00000051180
Uniprot IDs		P27694	Q06609
PDB IDs		1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH	1B22 1N0W
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair DNA Replication Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA-dependent DNA Replication Cellular Nitrogen Compound Metabolic Process DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromosome Organization Cell Cycle Checkpoint Nitrogen Compound Metabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Regulation Of Cell Cycle Response To Ionizing Radiation DNA Conformation Change Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Organelle Organization DNA Catabolic Process Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Response To Radiation Mitotic Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Cell Cycle Phase Transition DNA Strand Elongation Involved In DNA Replication Cellular Response To Stimulus Response To Abiotic Stimulus DNA Strand Elongation Signal Transduction In Response To DNA Damage Cellular Response To Ionizing Radiation Cellular Macromolecule Biosynthetic Process	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination Cellular Response To Stress Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Radiation Cellular Nitrogen Compound Metabolic Process Chromosome Organization Response To Ionizing Radiation Organelle Organization Cell Cycle Nitrogen Compound Metabolic Process Cellular Response To Stimulus DNA Duplex Unwinding DNA Geometric Change Response To Abiotic Stimulus Regulation Of Cell Cycle Response To Stimulus Cell Cycle Process DNA-dependent DNA Replication DNA Replication Signal Transduction In Response To DNA Damage Meiotic Nuclear Division Cellular Response To Ionizing Radiation DNA Conformation Change Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Cell Aging Response To UV Meiotic Cell Cycle Cellular Response To Radiation DNA Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Cellular Metabolic Process Replication Fork Processing Cellular Response To Hydroxyurea Intrinsic Apoptotic Signaling Pathway Meiosis I Response To Gamma Radiation Signal Transduction By P53 Class Mediator DNA Recombinase Assembly Regulation Of Response To DNA Damage Stimulus
Tagcloud ?		200a arthroplasty backgroundischemia conclusionsin david deeper degs downloaded gabp geo insults inverted ipc kegg limma mark0 mark1 meanwhile methodsgse21164 mir141 omnibus package ppi preconditioning reperfused resultssignificantly string t0 t1	boundary box cerevisiae consisting damaging declined delta dosage dsc1 elements enhances fluctuate fluctuation frequency mbf1 mbp1 mcb meiosis meiotic mitotic mlu rad54 recombination saccharomyces spore sporulation swi6 transcript viability
Tagcloud (Difference) ?		200a arthroplasty backgroundischemia conclusionsin david deeper degs downloaded gabp geo insults inverted ipc kegg limma mark0 mark1 meanwhile methodsgse21164 mir141 omnibus package ppi preconditioning reperfused resultssignificantly string t0 t1	boundary box cerevisiae consisting damaging declined delta dosage dsc1 elements enhances fluctuate fluctuation frequency mbf1 mbp1 mcb meiosis meiotic mitotic mlu rad54 recombination saccharomyces spore sporulation swi6 transcript viability
Tagcloud (Intersection) ?