GRK1 and RHO

Number of citations of the paper that reports this interaction (PMID 11498053)
35

Data Source:
HPRD (in vivo, in vitro)

		GRK1	RHO
Gene Name		G protein-coupled receptor kinase 1	rhodopsin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Disc Membrane	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Golgi-associated Vesicle Membrane Rough Endoplasmic Reticulum Membrane Photoreceptor Outer Segment Membrane Ciliary Membrane Photoreceptor Inner Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity	G-protein Coupled Receptor Activity Protein Binding Photoreceptor Activity Retinal Binding Spectrin Binding Metal Ion Binding
	Biological Process	Visual Perception Phototransduction, Visible Light Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Photoreceptor Cell Morphogenesis Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Protein Autophosphorylation Post-embryonic Retina Morphogenesis In Camera-type Eye	Retinoid Metabolic Process Protein Phosphorylation Organelle Organization G-protein Coupled Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Red, Far-red Light Phototransduction Rhodopsin Mediated Signaling Pathway Protein-chromophore Linkage Regulation Of Rhodopsin Mediated Signaling Pathway Retina Development In Camera-type Eye
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Class A/1 (Rhodopsin-like receptors) Opsins VxPx cargo-targeting to cilium Assembly of the primary cilium Metabolic disorders of biological oxidation enzymes GPCR ligand binding Diseases associated with visual transduction Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade GPCR downstream signaling Visual phototransduction The phototransduction cascade The canonical retinoid cycle in rods (twilight vision) G alpha (i) signalling events
Drugs			Halothane N-Acetylmethionine 3-[Aminoethylphosphoryl]-[1,2-Di-Palmitoyl]-Sn-Glycerol Phosphonothreonine Beta-D-Mannose Alpha-D-Mannose B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Lauryl Dimethylamine-N-Oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane Heptyl 1-Thiohexopyranoside Phosphonoserine
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CALM1 CAV1 PDE6D RCVRN RHO SNCA SNCB SNCG	10 interactors: ADRBK1 ARR3 DERL1 GNGT1 GRK1 GRK5 GRK6 PPP2CA PRKCA SAG
Entrez ID		6011	6010
HPRD ID		01585	01584
Ensembl ID			ENSG00000163914
Uniprot IDs		Q15835	P08100
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Regulation Of Ion Transport Regulation Of Oxidoreductase Activity Phototransduction, Visible Light Regulation Of Calcium Ion Transport Into Cytosol Detection Of Visible Light Positive Regulation Of Calcium Ion Transport Cellular Response To Light Stimulus Phototransduction Negative Regulation Of Ion Transport Detection Of Light Stimulus Negative Regulation Of Monooxygenase Activity Response To Abiotic Stimulus Response To Inorganic Substance Cellular Response To Radiation Regulation Of Ion Homeostasis Regulation Of Dopamine Secretion Synapse Organization Visual Perception Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Synaptic Transmission Regulation Of Catalytic Activity Negative Regulation Of Oxidoreductase Activity Positive Regulation Of Ion Transport Dopamine Metabolic Process Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Transporter Activity Catecholamine Metabolic Process Receptor Internalization Positive Regulation Of Lyase Activity Regulation Of Signaling Negative Regulation Of Ion Transmembrane Transport Response To Cocaine Response To Organic Cyclic Compound Response To External Stimulus Negative Regulation Of Protein Phosphorylation Cell-cell Signaling Response To Metal Ion Negative Regulation Of Transmembrane Transport Response To Light Stimulus	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Phototransduction, Visible Light Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Light Stimulus Cellular Response To Radiation Signal Transduction Detection Of Abiotic Stimulus Signaling Cell Communication Regulation Of Signal Transduction Negative Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Response To Light Stimulus Apoptotic Process Response To Radiation Response To Stimulus Programmed Cell Death Cell Death Death Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Detection Of Stimulus Response To Fibroblast Growth Factor Cellular Protein Modification Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Protein Autophosphorylation Protein Phosphorylation Peptidyl-threonine Phosphorylation Photoreceptor Cell Development Activation Of Phospholipase C Activity Protein Metabolic Process Positive Regulation Of Phospholipase C Activity Nuclear Envelope Organization Negative Regulation Of Apoptotic Process
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk2 grk4 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 seemed steps takes tc10 vdr
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk2 grk4 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 seemed steps takes tc10 vdr
Tagcloud (Intersection) ?