RFC4 and RFC2

Number of citations of the paper that reports this interaction (PMID 9092549)
39

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		RFC4	RFC2
Gene Name		replication factor C (activator 1) 4, 37kDa	replication factor C (activator 1) 2, 40kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Cytoplasm	Nucleus Nucleoplasm DNA Replication Factor C Complex Golgi Apparatus
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding	DNA Clamp Loader Activity Protein Binding ATP Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication
Pathways		Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints	Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		11 interactors: BRD4 CDK4 CHTF18 HDAC1 PCNA RAD17 RFC1 RFC2 RFC3 RFC5 RNF41	8 interactors: BRD4 PCNA PRKAR1A RAD17 RAD18 RFC1 RFC4 RFC5
Entrez ID		5984	5982
HPRD ID		00022	02675
Ensembl ID		ENSG00000163918	ENSG00000049541
Uniprot IDs		P35249	P35250 Q75MT5
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Mitotic Cell Cycle Cell Cycle Transcription-coupled Nucleotide-excision Repair DNA Replication Cell Cycle Process Telomere Maintenance Nucleotide-excision Repair DNA Recombination DNA-dependent DNA Replication Chromosome Organization Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Repair Organelle Organization Cellular Response To Stress Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Homeostasis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Response To Stimulus Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Stimulus Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Homeostatic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Deoxyribonuclease Activity	Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus DNA Repair Telomere Maintenance DNA Replication Cell Cycle Nucleotide-excision Repair Mitotic Cell Cycle DNA-dependent DNA Replication Cellular Response To Stress Cell Cycle Process DNA Metabolic Process Response To Stress DNA Recombination Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Homeostatic Process Cellular Response To Stimulus Cellular Homeostasis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Response To Stimulus Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of DNA Metabolic Process Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Leading Strand Elongation Regulation Of DNA Replication Cellular Metabolic Process Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Damage Checkpoint Histone H3-K14 Acetylation Biosynthetic Process Cell Proliferation Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc3 rfc5	12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc3 rfc4 rfc5
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc3 rfc4 rfc5