RFC2 and RAD17

Number of citations of the paper that reports this interaction (PMID 14605214)
124

Data Source:
BioGRID (pull down)

		RFC2	RAD17
Gene Name		replication factor C (activator 1) 2, 40kDa	RAD17 homolog (S. pombe)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Golgi Apparatus	Chromosome, Telomeric Region Nucleus Nucleoplasm
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding	Protein Binding ATP Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Replication Regulation Of Phosphorylation
Pathways		Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints	G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: BRD4 PCNA PRKAR1A RAD17 RAD18 RFC1 RFC4 RFC5	16 interactors: ATM ATR HUS1 MCM7 NHP2L1 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 RFC5 USP20
Entrez ID		5982	5884
HPRD ID		02675	09124
Ensembl ID		ENSG00000049541	ENSG00000152942
Uniprot IDs		P35250 Q75MT5	O75943
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus DNA Repair Telomere Maintenance DNA Replication Cell Cycle Nucleotide-excision Repair Mitotic Cell Cycle DNA-dependent DNA Replication Cellular Response To Stress Cell Cycle Process DNA Metabolic Process Response To Stress DNA Recombination Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Homeostatic Process Cellular Response To Stimulus Cellular Homeostasis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Response To Stimulus Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of DNA Metabolic Process Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Leading Strand Elongation Regulation Of DNA Replication Cellular Metabolic Process Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Damage Checkpoint Histone H3-K14 Acetylation Biosynthetic Process Cell Proliferation Regulation Of Nitrogen Compound Metabolic Process	Cellular Response To DNA Damage Stimulus DNA Repair DNA Replication DNA Metabolic Process Cell Cycle Process Cellular Response To Stress DNA Recombination Telomere Maintenance Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Damage Checkpoint Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Cell Cycle Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Checkpoint DNA-dependent DNA Replication Response To Stress Response To Ionizing Radiation Nucleobase-containing Compound Metabolic Process Cellular Response To Ionizing Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleotide-excision Repair Chromosome Organization Nitrogen Compound Metabolic Process Cellular Response To Radiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Radiation Biosynthetic Process Cellular Response To Stimulus Cellular Metabolic Process Double-strand Break Repair Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint Response To Gamma Radiation Organelle Organization Negative Regulation Of Cell Cycle Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Mitotic Cell Cycle Homeostatic Process
Tagcloud ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc3 rfc4 rfc5	acetylcysteine antioxidant chk1 converted depleted driving experiencing gamma h2ax h2o2 illustrate instability intertwined micronuclei mildly mimics mn nac p400 pan peroxide promoting redox reinforce rnai ros sesn1 stressed subclass
Tagcloud (Difference) ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc3 rfc4 rfc5	acetylcysteine antioxidant chk1 converted depleted driving experiencing gamma h2ax h2o2 illustrate instability intertwined micronuclei mildly mimics mn nac p400 pan peroxide promoting redox reinforce rnai ros sesn1 stressed subclass
Tagcloud (Intersection) ?