REN and M6PR

Number of citations of the paper that reports this interaction (PMID 2960682)
11

Data Source:
HPRD (in vitro)

		REN	M6PR
Gene Name		renin	mannose-6-phosphate receptor (cation dependent)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane	Lysosomal Membrane Endosome Late Endosome Integral Component Of Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Aspartic-type Endopeptidase Activity Receptor Binding Insulin-like Growth Factor Receptor Binding Peptidase Activity	Transmembrane Signaling Receptor Activity Mannose Binding Mannose Transmembrane Transporter Activity
	Biological Process	Kidney Development Mesonephros Development Angiotensin Maturation Renin-angiotensin Regulation Of Aldosterone Production Proteolysis Regulation Of Blood Pressure Male Gonad Development Hormone-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Drug Response To Immobilization Stress Drinking Behavior Regulation Of MAPK Cascade Cellular Protein Metabolic Process Cell Maturation Beta-amyloid Metabolic Process Response To CAMP Response To CGMP	Receptor-mediated Endocytosis Signal Transduction Endosome To Lysosome Transport Mannose Transport
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins	trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Lysosome Vesicle Biogenesis
Drugs		Remikiren Aliskiren Dimethylformamide 1-Hydroxy-3-Methylbutane 3-Phenyl-1,2-Propandiol 2-Methyl-3-(2-Aminothiazolo)Propanal Enalkiren 2-Cyclopropylmethylenepropanal 1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine N-Methyl-N-(Methylbenzyl)Formamide 1-Hydroxy-2-Amino-3-Cyclohexylpropane N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE 6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE 6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE 6-ETHYL-5-[(2S)-1-(3-METHOXYPROPYL)-2-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-7-YL]PYRIMIDINE-2,4-DIAMINE
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AGT ATP6AP2 CTSB KCTD15 M6PR PCSK1 PCSK5 RENBP	6 interactors: GGA1 GGA2 GGA3 JUN PLIN3 REN
Entrez ID		5972	4074
HPRD ID		01564	01106
Ensembl ID		ENSG00000143839	ENSG00000003056
Uniprot IDs		P00797	P20645
PDB IDs		1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN 2V0Z 2V10 2V11 2V12 2V13 2V16 2X0B 3D91 3G6Z 3G70 3G72 3GW5 3K1W 3KM4 3O9L 3OAD 3OAG 3OOT 3OQF 3OQK 3OWN 3Q3T 3Q4B 3Q5H 3SFC 3VCM 3VSW 3VSX 3VUC 3VYD 3VYE 3VYF 4AMT 4GJ5 4GJ6 4GJ7 4GJ8 4GJ9 4GJA 4GJB 4GJC 4GJD	1JUQ
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Peptide Metabolic Process Regulation Of Blood Pressure Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Blood Circulation Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Peptide Biosynthetic Process Female Pregnancy Uterine Smooth Muscle Contraction Mannose Transport Renin Secretion Into Blood Stream Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Renal System Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity N-acetylmannosamine Metabolic Process Catenin Import Into Nucleus Protein Secretion Cytokine Production Proteolysis Smooth Muscle Cell Proliferation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Angiotensin-mediated Drinking Behavior Regulation Of Renal Output By Angiotensin Nerve Growth Factor Processing Fibroblast Proliferation Astrocyte Activation N-acetylneuraminate Catabolic Process Renin-angiotensin Regulation Of Aldosterone Production Tube Development Regulation Of Blood Vessel Size By Renin-angiotensin Establishment Of Blood-nerve Barrier Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Activation Of JAK2 Kinase Activity Regulation Of NAD(P)H Oxidase Activity Eye Pigmentation Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Activation Of Janus Kinase Activity	Intracellular Protein Transport Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Cellular Response To Potassium Ion Starvation Response To CAMP Leading Edge Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Protein Localization Response To Organophosphorus Establishment Of Localization In Cell Response To Purine-containing Compound Regulation Of Protein Metabolic Process Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Protein Catabolic Process Cellular Localization Positive Regulation Of Monocyte Differentiation Drinking Behavior Response To CGMP Transport SMAD Protein Import Into Nucleus Positive Regulation By Host Of Viral Transcription Response To Lipopolysaccharide Negative Regulation By Host Of Viral Transcription Angiotensin Maturation Response To Molecule Of Bacterial Origin Regulation Of Angiotensin Metabolic Process Negative Regulation Of Protein Autophosphorylation Regulation Of Blood Volume By Renin-angiotensin Microglial Cell Activation Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Monocyte Differentiation Regulation Of Protein Catabolic Process Monocyte Differentiation Negative Regulation Of Viral Transcription Beta-amyloid Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Immobilization Stress Response To Bacterium Response To Drug Negative Regulation Of Neuroblast Proliferation
Tagcloud ?		4f analogue ant biol brought cap chem eif embo environmentally goss iso le m7g m7gppx m7gtp nucleic pabp poly proximity recycling res ribosome sachs synergistically tail tarun translational whereby	cathepsin compartment degraded dissociates distributed en endocytic endosome enriched fuse golgi hep internalized leaves lysosome lysosomes multivesicular mvb mvbs prelysosomal prelysosome pulse return route routed steady trans vacuolar vacuoles
Tagcloud (Difference) ?		4f analogue ant biol brought cap chem eif embo environmentally goss iso le m7g m7gppx m7gtp nucleic pabp poly proximity recycling res ribosome sachs synergistically tail tarun translational whereby	cathepsin compartment degraded dissociates distributed en endocytic endosome enriched fuse golgi hep internalized leaves lysosome lysosomes multivesicular mvb mvbs prelysosomal prelysosome pulse return route routed steady trans vacuolar vacuoles
Tagcloud (Intersection) ?