REN and AGT

Number of citations of the paper that reports this interaction (PMID 12045255)
150

Data Source:
BioGRID (enzymatic study, x-ray crystallography, enzymatic study)

		REN	AGT
Gene Name		renin	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Aspartic-type Endopeptidase Activity Receptor Binding Insulin-like Growth Factor Receptor Binding Peptidase Activity	Serine-type Endopeptidase Inhibitor Activity Hormone Activity Protein Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Type 1 Angiotensin Receptor Binding Type 2 Angiotensin Receptor Binding
	Biological Process	Kidney Development Mesonephros Development Angiotensin Maturation Renin-angiotensin Regulation Of Aldosterone Production Proteolysis Regulation Of Blood Pressure Male Gonad Development Hormone-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Drug Response To Immobilization Stress Drinking Behavior Regulation Of MAPK Cascade Cellular Protein Metabolic Process Cell Maturation Beta-amyloid Metabolic Process Response To CAMP Response To CGMP	Ovarian Follicle Rupture Regulation Of Cell Growth Blood Vessel Development Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cytokine Production Kidney Development Blood Vessel Remodeling Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Renal Output By Angiotensin Regulation Of Blood Vessel Size By Renin-angiotensin Renal System Process Angiotensin-mediated Drinking Behavior Positive Regulation Of Extracellular Matrix Constituent Secretion Cellular Sodium Ion Homeostasis Cell-matrix Adhesion G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Activation Of NF-kappaB-inducing Kinase Activity Nitric Oxide Mediated Signal Transduction Cell-cell Signaling Female Pregnancy Aging Excretion Establishment Of Blood-nerve Barrier Negative Regulation Of Cell Proliferation Response To Cold Response To Salt Stress Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Negative Regulation Of Endopeptidase Activity Regulation Of Norepinephrine Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Negative Regulation Of Angiogenesis Regulation Of Vasoconstriction Extracellular Matrix Organization Negative Regulation Of Cell Growth Peristalsis Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Tissue Remodeling Low-density Lipoprotein Particle Remodeling Catenin Import Into Nucleus Regulation Of Renal Sodium Excretion Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Vasodilation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Metabolic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Positive Regulation Of Organ Growth Astrocyte Activation Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Smooth Muscle Cell Proliferation Cytokine Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Smooth Muscle Cell Differentiation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Regulation Of Calcium Ion Transport Regulation Of Transmission Of Nerve Impulse Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Protein Tyrosine Kinase Activity ERK1 And ERK2 Cascade Uterine Smooth Muscle Contraction Cellular Response To Mechanical Stimulus Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Metabolism of Angiotensinogen to Angiotensins G alpha (i) signalling events Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs		Remikiren Aliskiren Dimethylformamide 1-Hydroxy-3-Methylbutane 3-Phenyl-1,2-Propandiol 2-Methyl-3-(2-Aminothiazolo)Propanal Enalkiren 2-Cyclopropylmethylenepropanal 1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine N-Methyl-N-(Methylbenzyl)Formamide 1-Hydroxy-2-Amino-3-Cyclohexylpropane N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE 6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE 6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE 6-ETHYL-5-[(2S)-1-(3-METHOXYPROPYL)-2-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-7-YL]PYRIMIDINE-2,4-DIAMINE
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AGT ATP6AP2 CTSB KCTD15 M6PR PCSK1 PCSK5 RENBP	22 interactors: ACE2 AGTR1 AGTR2 ATP6AP2 CMA1 CTSG DNPEP ECE1 ENPEP EWSR1 GRB2 GSDMB ITSN2 KNG1 MAS1 MEP1A MME PRCP PREP PRG2 REN TP53
Entrez ID		5972	183
HPRD ID		01564	00106
Ensembl ID		ENSG00000143839	ENSG00000135744
Uniprot IDs		P00797	B0ZBE2 B2R5S1 P01019
PDB IDs		1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN 2V0Z 2V10 2V11 2V12 2V13 2V16 2X0B 3D91 3G6Z 3G70 3G72 3GW5 3K1W 3KM4 3O9L 3OAD 3OAG 3OOT 3OQF 3OQK 3OWN 3Q3T 3Q4B 3Q5H 3SFC 3VCM 3VSW 3VSX 3VUC 3VYD 3VYE 3VYF 4AMT 4GJ5 4GJ6 4GJ7 4GJ8 4GJ9 4GJA 4GJB 4GJC 4GJD	1N9U 1N9V 2JP8 2WXW 2X0B 4AA1 4APH 4FYS
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Peptide Metabolic Process Regulation Of Blood Pressure Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Blood Circulation Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Peptide Biosynthetic Process Female Pregnancy Uterine Smooth Muscle Contraction Mannose Transport Renin Secretion Into Blood Stream Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Renal System Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity N-acetylmannosamine Metabolic Process Catenin Import Into Nucleus Protein Secretion Cytokine Production Proteolysis Smooth Muscle Cell Proliferation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Angiotensin-mediated Drinking Behavior Regulation Of Renal Output By Angiotensin Nerve Growth Factor Processing Fibroblast Proliferation Astrocyte Activation N-acetylneuraminate Catabolic Process Renin-angiotensin Regulation Of Aldosterone Production Tube Development Regulation Of Blood Vessel Size By Renin-angiotensin Establishment Of Blood-nerve Barrier Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Activation Of JAK2 Kinase Activity Regulation Of NAD(P)H Oxidase Activity Eye Pigmentation Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Activation Of Janus Kinase Activity	Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of Blood Pressure Peptide Hormone Processing Blood Circulation Peptide Metabolic Process Cellular Amide Metabolic Process Regulation Of Hormone Levels Hormone Metabolic Process Protein Processing Regulation Of Blood Volume By Renin-angiotensin Proteolysis Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin-activated Signaling Pathway Regulation Of Protein Metabolic Process Peptide Catabolic Process Regulation Of Renal Sodium Excretion Regulation Of Excretion Renal System Process Angiotensin Catabolic Process In Blood Regulation Of Metabolic Process Multicellular Organismal Protein Catabolic Process Kidney Development Multicellular Organismal Protein Metabolic Process Regulation Of Blood Vessel Size By Renin-angiotensin Renal System Development Regulation Of Vasodilation Urogenital System Development Regulation Of Vasoconstriction Drinking Behavior Brain Renin-angiotensin System Regulation Of Blood Vessel Size Regulation Of Tube Size System Development Positive Regulation Of Renal Sodium Excretion Organ Development Blood Coagulation, Intrinsic Pathway Regulation Of Inflammatory Response Negative Regulation Of Systemic Arterial Blood Pressure Replicative Senescence Regulation Of Signaling Extracellular Negative Regulation Of Signal Transduction Beta-amyloid Metabolic Process Digestion Protein Metabolic Process
Tagcloud ?		4f analogue ant biol brought cap chem eif embo environmentally goss iso le m7g m7gppx m7gtp nucleic pabp poly proximity recycling res ribosome sachs synergistically tail tarun translational whereby	agc alleles amplified autophosphorylation berardinelli changing coding codon exons heterozygous iinsulin inheritance insulin lesion lipodystrophic lipodystrophy mellitus outside pathogenetic polymorphism polymorphisms recessive seip sequenced ser339 silent substitution unlikely val
Tagcloud (Difference) ?		4f analogue ant biol brought cap chem eif embo environmentally goss iso le m7g m7gppx m7gtp nucleic pabp poly proximity recycling res ribosome sachs synergistically tail tarun translational whereby	agc alleles amplified autophosphorylation berardinelli changing coding codon exons heterozygous iinsulin inheritance insulin lesion lipodystrophic lipodystrophy mellitus outside pathogenetic polymorphism polymorphisms recessive seip sequenced ser339 silent substitution unlikely val
Tagcloud (Intersection) ?