CARD17 and CARD18

Number of citations of the paper that reports this interaction (PMID 15383541)
19

Data Source:
HPRD (in vitro, in vivo)

		CARD17	CARD18
Gene Name		caspase recruitment domain family, member 17	caspase recruitment domain family, member 18
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cellular_component
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity	Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process	Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CARD16 CARD18 CASP1	2 interactors: CARD17 CARD8
Entrez ID		440068	59082
HPRD ID		17149	16099
Ensembl ID		ENSG00000255221	ENSG00000255501
Uniprot IDs		Q5XLA6	P57730
PDB IDs			1DGN
Enriched GO Terms of Interacting Partners?		Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Mitochondrial Depolarization Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Interleukin-1 Alpha Secretion Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Pyroptosis Positive Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Protein Processing Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Catalytic Activity Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Catalytic Activity Response To ATP Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Protein Metabolic Process Membrane Hyperpolarization Toxin Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Necrotic Cell Death Necrotic Cell Death Regulation Of Interleukin-1 Beta Production Cellular Response To Mechanical Stimulus Defense Response Execution Phase Of Apoptosis Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Autophagy Membrane Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Cytokine Production Positive Regulation Of Peptidase Activity	Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Apoptotic Process Regulation Of Interleukin-1 Beta Production Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Metabolic Process Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Positive Regulation Of Peptidase Activity Positive Regulation Of Protein Secretion Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity
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