PYCR1 and BNIPL

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PYCR1	BNIPL
Gene Name		pyrroline-5-carboxylate reductase 1	BCL2/adenovirus E1B 19kD interacting protein like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytosol
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Proline Biosynthetic Process Cellular Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Regulation Of Mitochondrial Membrane Potential Oxidation-reduction Process L-proline Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Apoptotic Process Negative Regulation Of Cell Proliferation Regulation Of Growth Rate
Pathways		Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives
Drugs		NADH L-Proline
Diseases
GWAS			Chronic kidney disease ( 20383146)
Protein-Protein Interactions		4 interactors: BNIPL CDK2AP2 HNRNPD NUDT21	14 interactors: ARHGAP1 BAX BCL2 BCL2L1 BNIP2 CDC42 FKBP8 GFER MIF NME2 PXDN PYCR1 RECQL5 SNAPIN
Entrez ID		5831	149428
HPRD ID		01528	16557
Ensembl ID		ENSG00000183010	ENSG00000163141
Uniprot IDs		B4DMU0 E2QRB3 P32322 Q8TBX0	Q7Z465
PDB IDs		2GER 2GR9 2GRA 2IZZ
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Growth Rate RNA Splicing Circadian Regulation Of Translation MRNA Processing MRNA Metabolic Process RNA Processing MRNA Polyadenylation RNA Polyadenylation Termination Of RNA Polymerase II Transcription Regulation Of MRNA Stability Regulation Of RNA Stability	Regulation Of Mitochondrial Membrane Potential Regulation Of Protein Heterodimerization Activity Negative Regulation Of Cell Death Regulation Of Cell Death Ovarian Follicle Development Positive Regulation Of Signal Transduction Ovulation Cycle Process Negative Regulation Of Apoptotic Process Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Programmed Cell Death Female Gonad Development Regulation Of Apoptotic Process Ovulation Cycle Development Of Primary Female Sexual Characteristics Release Of Cytochrome C From Mitochondria Regulation Of Nitrogen Utilization Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Protein Binding Mitochondrial Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Gamma Radiation Male Sex Differentiation Positive Regulation Of Intracellular Signal Transduction Neuron Apoptotic Process Regulation Of Signal Transduction Regulation Of Cell Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Neuron Death Positive Regulation Of Cell Development Gonad Development Apoptotic Mitochondrial Changes Development Of Primary Sexual Characteristics Regulation Of Neuron Apoptotic Process Positive Regulation Of Intracellular Transport Germ Cell Development Regulation Of Signaling Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Binding Regulation Of Cellular Localization Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Membrane Potential Positive Regulation Of Muscle Cell Differentiation Regulation Of Neuron Death Negative Regulation Of Signal Transduction Sex Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Tagcloud ?			allowing alters antagonization antagonize antiapoptotic bag1 bcl bcl2l13 becn1 bmf bnip1 bnip3 clu conditional considering erbb2 influences influencing master mcl members proapoptotic prognosis prototypic relevance remission substitute tegt whereby
Tagcloud (Difference) ?			allowing alters antagonization antagonize antiapoptotic bag1 bcl bcl2l13 becn1 bmf bnip1 bnip3 clu conditional considering erbb2 influences influencing master mcl members proapoptotic prognosis prototypic relevance remission substitute tegt whereby
Tagcloud (Intersection) ?